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20 Cards in this Set
- Front
- Back
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what is type 2 diabetes |
deficit in insulin and decrease in tissue sensitivity to insulin insulin resistance increased glucose production in the liver poor beta cell function |
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what are the drugs for type 2 diabetes |
Biguanides (Metformin) Sulfonylureas Thiazolidinediones DPP-IV Inhibitors SGLT2 Inhibtors Meglitinide Analogs Alpha-glucosidase Inhibitors GLP-1 agonists |
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ADR of biguanides |
GI: nausea, indigestion, abdominal cramps, bloating, diarrhea, or combo |
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who are bad candidates for biguanides |
renal impariment (1.4ml/dl) heart failure uncontrolled respiratory disease |
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dose for biguanides |
Metformin 500mg T BID with meals |
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ADR of sulfonylureas |
low rate: HA, nausea, hypoglycemia cardiovascular mortality
drug:drug interactions: NSAIDs, BB, warfarin increase hypoglycemic effect, thiazides, steroids, thyroid preps, estrogen decrease hypoglycemic effect
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dose for sulfonylureas |
Glimepiride 1mg T qd with breakfast |
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ADR of thiazolidendiones |
NO hypoglycemia rare liver issues (check q 2mo) fluid retention |
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dose for thiazolidendiones |
Pioglitazone 15mg T qd |
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what DPP-IV inhibitors need renal impairment dosing adjustments |
Alogliptin (Nesina) Saxagliptin (Onglyza) Sitagliptin (Januvia) |
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which DPP-IV inhibitors can cause drug interactions |
Saxagliptin (Onglyza) Lingliptin (tradjenta) |
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ADR of DPP-IV inhibitors |
low nasopharyngitis, URI allergic rxn |
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dose for DPP-IV inhibitors |
Januvia 100mg qd |
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ADR of GLP-1 receptor agonists |
GI: n/v/d delay in gastic emptying time renal issues |
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dose for GLP-1 receptor agonists |
Victoza 18mg/3mL inject 1.2mg SQ qd |
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ADR of SGLT2 inhibitors |
HOTN (from dehydration) hyperkalemia infx (UTI, genital mycotic infx) increase in LDL-C increase in blade and breast CA risk |
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dose for SGLT2 inhibitors |
Invokana 300mg T qd |
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dose for meglitinide analogs |
Prandin 0.5mg T before each meal |
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ADR of alpha-glucosidase inhibitor |
diarrhea, abd pain, flatulence hypoglycemia risk is gone unless pt uses insulin or sulfonylurea |
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dose for alpha-glucosidase inhibitor |
Precose 100mg T with first bite of a meal |
