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62 Cards in this Set
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actinic keratosis
rough, scaling, reddish, ill-defined patch or plaque |
UV radiation induced, can spontaneously regress or progress to SCC
may form horn-like excrescences (need to biopsy). inflammatory infiltrate and solar elastosis (sun damage) common full thickness dysplasia = SCC in situ |
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actinic keratosis
variable atypia (less than full thickness), solar elastosis, chronic dermal inflammation |
UV radiation induced, can spontaneously regress or progress to SCC
may form horn-like excrescences (need to biopsy). inflammatory infiltrate and solar elastosis (sun damage) common full thickness dysplasia = SCC in situ |
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actinic keratosis
variable atypia (less than full thickness), solar elastosis, chronic dermal inflammation |
UV radiation induced, can spontaneously regress or progress to SCC
may form horn-like excrescences (need to biopsy). inflammatory infiltrate and solar elastosis (sun damage) common full thickness dysplasia = SCC in situ |
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angiocentric
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associated w/ urticaria and necrotizing vasculitis
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angiocentric
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associated w/ urticaria and necrotizing vasculitis
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atrophy
dermal/subcutaneous |
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BCC
erythematous patch w/ central erosion/ulceration and rolled pearly border w/ telangiectasia or pearly papule or nodule w/ telangiectasias |
sun exposed skin, most common skin cancer (most common human malignancy)
rarely metastasizes, locally aggressive |
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BCC
enlarged basaloid keratinocytes mitosis, individual cell necrosis, peripheral palisading, separation artifact |
sun exposed skin, most common skin cancer (most common human malignancy)
rarely metastasizes, locally aggressive |
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BCC
superficial type |
sun exposed skin, most common skin cancer (most common human malignancy)
rarely metastasizes, locally aggressive |
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dermatitis herpetiformis (celiac dz)
microabcesses and neutrophils |
IgA-TeG (antiendomysial Ab) deposition from gluten sensitivity causes blistering and herpetiform
Tx: Dapsone (skin symptoms), gluten free diet (systemic symptoms) |
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compound melanocytic nevus
melanocytes in dermis and epidermis |
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discoid lupus
localized to skin (5-10% have SLE), pigment change, telangiectasia, alopecia, follicular plugging |
autoimune interface dermatitis
may be entirely localized to skin chronic atrophy of skin, pigment change due to damage to basal layer |
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discoid lupus
epidermal atrophy, hyperkeratosis, lymphocytes attacking DEJ, follicular destruction, dilated vessels, positive "lupus band" |
autoimune interface dermatitis
may be entirely localized to skin chronic atrophy of skin, pigment change due to damage to basal layer |
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dysplastic nevus
irregular nests, bridging, shoulder, cytologic atypia, lamellar fibroplasia |
melanoma precursor
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dysplastic nevus
irregular nests, bridging, shoulder, cytologic atypia, lamellar fibroplasia |
melanoma precursor
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Erythema Nodosum
panniculitis chronic inflammation (lymphocytes, histiocytes, eos, granulomas) septal firborsis |
often provoked by infection, drug ingestion, or associated systemic inflammatory disorder (most common cause is idiopathic)
tender subc nodules |
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Erythema Nodosum
panniculitis chronic inflammation (lymphocytes, histiocytes, eos, granulomas) septal firborsis |
often provoked by infection, drug ingestion, or associated systemic inflammatory disorder (most common cause is idiopathic)
tender subc nodules |
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inflammation
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angiocentric/spongiotic/interface
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inflammation
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vesiculobullous/panniculitic
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interface infiltrated
Discoid Lupus Erythematosis |
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Lichen Planus
pink purple pruritic polygonal papules or plaques often on wrists/ancles |
interface dermatoses
most cases idiopathic, koebner phenom, lymphocytes attacking keratinocytes |
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Lichen Planus
Interface dermatoses w/ lymphocytes obscuring keratinocytes |
interface dermatoses
most cases idiopathic, koebner phenom, lymphocytes attacking keratinocytes |
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melanocytes
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melanocytic nevus
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most acquired btwn 6 and 35
variable but uniform appearance brown to flesh colored, <5mm diameter |
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melanocytic nevus
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most acquired btwn 6 and 35
variable but uniform appearance brown to flesh colored, <5mm diameter |
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melanocytic nevus
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most acquired btwn 6 and 35
variable but uniform appearance brown to flesh colored, <5mm diameter |
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melanoma in situ
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melanoma cells confined to the epidermal layer
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acral melanoma
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most common type of melanoma in dark skinned pts
nail beds and soles of feet |
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necrotizing vasculitis
palpable purpura |
can be limited to skin or systemic, non blanching (extravasated RBCs)
Drugs, infection, connective tissue Dz, underlying malignancy may cause Typically IgG Henoch-Schonlein Purpura an IgA variant more common in peds requiring serial UAs |
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normal skin
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normal skin
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normal skin
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Hyperplasia (Acanthosis)/Dysplasia
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Psoriatic Arthritis
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gross
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psoriasis
erythematous plaques w/ silvery scales |
Koebner Phenom, Auspitz sign
HLA types (genetic factor) neutrophils arthritic lesions may present autoreactive T Cells? |
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psoriasis
"regular" acanthosis parakeratosis neutrophils loss of granular layer suprapapillary dermal plate prominent dilated capillaries |
Koebner Phenom, Auspitz sign
HLA types (genetic factor) neutrophils arthritic lesions may present autoreactive T Cells? |
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psoriasis
"regular" acanthosis parakeratosis neutrophils loss of granular layer suprapapillary dermal plate prominent dilated capillaries |
Koebner Phenom, Auspitz sign
HLA types (genetic factor) neutrophils arthritic lesions may present autoreactive T Cells? |
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Pemphigus Vulgaris
flacid easily ruptured blisters Nikolsky sign |
genetic predisposition, 40s-50s
autoimmune attack of IgG against desmoglein 3 uniformly fatal before steroid therapy available |
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Pemphigus Vulgaris
tombstone pattern, basal layer still attached |
genetic predisposition, 40s-50s
autoimmune attack of IgG against desmoglein 3 uniformly fatal before steroid therapy available |
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Pemphigus Vulgaris
immunofluorescence for IgG against Desmoglein 3 Lace of fish scale pattern differentiates from lupus or dermatitis herpetiformis |
genetic predisposition, 40s-50s
autoimmune attack of IgG against desmoglein 3 uniformly fatal before steroid therapy available |
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Squamous Cell Carcinoma
scaling erythematous plaque or nodule |
occurs often on sun-exposed skin or mucous membrane or sites of chronic injury
locally invasive small potential to metastasize |
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Squamous Cell Carcinoma
atypical keratinocytes, growth into underlying dermis, keratin pearls, hyperkeratosis, parakeratosis |
occurs often on sun-exposed skin or mucous membrane or sites of chronic injury
locally invasive small potential to metastasize |
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Squamous Cell Carcinoma
atypical keratinocytes, growth into underlying dermis, keratin pearls, hyperkeratosis, parakeratosis |
occurs often on sun-exposed skin or mucous membrane or sites of chronic injury
locally invasive small potential to metastasize |
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seborrheic keratosis
"stuck on" plaque or papule rough surface |
middle age and older
Sign of Leser-Trelat = many SKs in short time a result of internal malignancy possible environmental cause |
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seborrheic keratosis
no melanocytic incr horn cytsts of onion like laminated whorls |
middle age and older
Sign of Leser-Trelat = many SKs in short time a result of internal malignancy possible environmental cause |
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seborrheic keratosis
no melanocytic incr horn cytsts of onion like laminated whorls |
middle age and older
Sign of Leser-Trelat = many SKs in short time a result of internal malignancy possible environmental cause |
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seborrheic keratosis
no melanocytic incr horn cytsts of onion like laminated whorls |
seborrheic keratosis
no melanocytic incr horn cytsts of onion like laminated whorls |
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Allergic contact dermatitis
pruritic well demarcated erythematous edematous papules and plaques with vesicle formation often linear |
blister in 1-2 days
scaly w/ chronicity type IV hypersensitivity reaction (cell-mediated, delayed) (Langerhans present to naive T cells --> itchy) initial type I reaction may also be present initially |
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Allergic contact dermatitis
spongiotic reaction intercellular edema, vesicles may form btwn keratinocytes perivascular infiltrate of lymphocytes, histiocytes, and eos |
blister in 1-2 days
scaly w/ chronicity type IV hypersensitivity reaction (cell-mediated, delayed) (Langerhans present to naive T cells --> itchy) initial type I reaction may also be present initially |
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Allergic contact dermatitis
spongiotic reaction intercellular edema, vesicles may form btwn keratinocytes perivascular infiltrate of lymphocytes, histiocytes, and eos |
blister in 1-2 days
scaly w/ chronicity type IV hypersensitivity reaction (cell-mediated, delayed) (Langerhans present to naive T cells --> itchy) initial type I reaction may also be present initially |
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Storage deposition
solar elastosis/amyloid |
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Allergic contact dermatitis
spongiotic reaction intercellular edema, vesicles may form btwn keratinocytes perivascular infiltrate of lymphocytes, histiocytes, and eos |
blister in 1-2 days
scaly w/ chronicity type IV hypersensitivity reaction (cell-mediated, delayed) (Langerhans present to naive T cells --> itchy) initial type I reaction may also be present initially |
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urticaria
angiocentric inflammation dermatographism, tempurature sensitive vascular dilation, dermal edema |
often in young adults
<24 hrs, intensly pruritic, angioedema chronic forms: urticarial vasculitis, underlying dz IgE/mast cell/PG reaction angioedema in airways a immediate life threat |
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urticaria
angiocentric inflammation dermatographism, tempurature sensitive vascular dilation, dermal edema |
often in young adults
<24 hrs, intensly pruritic, angioedema chronic forms: urticarial vasculitis, underlying dz IgE/mast cell/PG reaction angioedema in airways a immediate life threat |
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urticaria
angiocentric inflammation dermatographism, tempurature sensitive vascular dilation, dermal edema |
often in young adults
<24 hrs, intensly pruritic, angioedema chronic forms: urticarial vasculitis, underlying dz IgE/mast cell/PG reaction angioedema in airways a immediate life threat |
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urticaria
angiocentric inflammation dermatographism, tempurature sensitive vascular dilation, dermal edema |
often in young adults
<24 hrs, intensly pruritic, angioedema chronic forms: urticarial vasculitis, underlying dz IgE/mast cell/PG reaction angioedema in airways a immediate life threat |
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urticaria
angiocentric inflammation dermatographism, tempurature sensitive vascular dilation, dermal edema |
often in young adults
<24 hrs, intensly pruritic, angioedema chronic forms: urticarial vasculitis, underlying dz IgE/mast cell/PG reaction angioedema in airways a immediate life threat |
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Verruca Vulgaris
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HPV
benign squamoid proliferation, koilocytosis |
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verruca vulgaris
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HPV
benign squamoid proliferation, koilocytosis |
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verruca vulgaris
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HPV
benign squamoid proliferation, koilocytosis |
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seborrheic keratosis
"stuck on" plaque or papule rough surface |
middle age and older
Sign of Leser-Trelat = many SKs in short time a result of internal malignancy possible environmental cause |
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seborrheic keratosis
"stuck on" plaque or papule rough surface |
middle age and older
Sign of Leser-Trelat = many SKs in short time a result of internal malignancy possible environmental cause |
