Depression And Anxiety

Front 1

MOA of SSRIs

Back 1

Selectively inhibit the neuronal re-uptake of 5-HT, thus enhancing synaptic concentrations of 5-HT and downregulating presynaptic 5-HT receptors

Front 2

Other than depression, what are some SSRIs licensed in?

Back 2

Anxiety disorders

Panic disorders

OCD

Front 3

MOA of TCAs

Back 3

Inhibit the neuronal uptake of NA and 5-HT leading to augmented concentrations in the synaptic cleft.

The increase in catecholamines may lead to down-regulation of presynaptic a-2 adrenoceptors and 5-HT receptors and postsynaptic b-adrenoceptors

Front 4

Antimuscarinic SEs of TCAs

Back 4

Dry mouth

Blurred vision

Constipation

Urinary retention

Sedation

Reduced motor co-ordination

Front 5

Cardiac effects of TCAs

Back 5

QT interval prolongation

Potentiation of catecholamines also predisposes to heart block and arrhythmias

Front 6

MOA of NARIs

Back 6

Selectively inhibit NA reuptake

Front 7

When are NARIs used?

Back 7

For patients who cannot take TCAs but are resistant to the effects of SSRIs

Front 8

MOA of SNRIs?

Back 8

Inhibits serotonin and NA reuptake

Front 9

What are SNRIs associated with causing?

Back 9

HTN

Front 10

MOA of NaSSAs

Back 10

Alpha2-adrenoceptor antagonist activity, inhibiting negative feedback by these presynaptic receptors and thus producing an increase in NA and 5-HT transmission

Front 11

SEs of NaSSAs

Back 11

Sedation in early treatment

Front 12

MOA of SRMs

Back 12

Serotonin receptor modulators

Inhibition of serotonin re-uptake and the selective inhibition of postsynaptic serotonin receptors

Front 13

First line treatment for bipolar affective disorder?

Back 13

Lithium (for both acute treatment and prophylaxis)

Front 14

When should lithium be avoided?

Back 14

In renal impairment

Front 15

What is required during lithium treatment?

Back 15

Therapeutic drug monitoring

Front 16

Which other drugs are used in bipolar affective disorder?

Back 16

Anticonvulsants: carbamazepine and valproate

Neuroleptics (antipsychotics)

Front 17

Basis of anxiety treatment?

Back 17

Benzodiazepines or beta blockers may offer symptomatic relief.

Antidepressants may improve the long term outcome

Front 18

What is buspirone?

Back 18

Activates 5-HT (1a) receptors, binds to dopamine receptors

Delay of 2-3 weeks prior to an anxiolytic effect

Front 19

SEs of buspirone?

Back 19

Dizziness

Nausea

Headache