Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
22 Cards in this Set
- Front
- Back
what does an acute phase response occur in association with?
|
infection, trauma, infarction, inflammation and various neoplasms.
|
|
What is the response of ESR to a disease state?
|
ESR is slow to rise [days] and slow to decrease after resolution/treatment [days/weeks].
|
|
What are 4 causes of signficantly raised ESR? (>100mm/hour)
|
•1.Temporal arteritis,
•2.Polymyalgia rheumatica •3.Infectious disease [Tuberculosis] •4.Neoplasm [Multiple Myeloma] |
|
what values of CRP indicate that an infection?
|
For most clinical purposes, CRP <3 mg/L can be regarded as normal and >10 mg/L as indicating clinically significant inflammation.
|
|
why may ESR be raised and CRP normal?
|
1. false positive
2. SLE (ESR may be a predictor or organ damage in SLE and of disease activity) |
|
what is normal ESR?
|
<35 mm/hour
|
|
1. What is an improved test (better than RF) for rheumatoid disease?
2. what is the reference range for RF? |
1. Anti-CCP (anti-cyclic citrillated peptide)
2. <20 IU/mL |
|
How is ANF (anti-nuclear factor) interpreted?
|
1. Weak + (1:40 and 1:100) (only rarely associated with connective tissue disease
2. strong + (1:400 or more) need more testing (anti-DNA or ENA) 3. - result (SLE and connective tissue dz unlikely) *interpretation is dependent on the clinical situation and age, sex of patient |
|
what are the patterns of ANF?
|
1. homogenous (non-specific)
2. speckled, non-specific 3. centromere 4. nucleolar |
|
what is typically positive in CREST? anything else?
|
anti-centromere (limitied dz). can also be + in billary cirrhosis
|
|
what is anti-nucleolar antibody pattern in?
|
scleroderma
also in autoimmune liver disease |
|
anti-dsDNA is found in...
|
SLE
autoimmune hepatitis *half life of IgM is 3 weeks, so measure monthly |
|
PR3-ANCA:
|
vasculitis...esp Wegeners
|
|
MPO-ANCA:
|
pauclimmune glomerulonephritis
|
|
anti-cardiolipin:
|
anti-phospholipid syndrome. (arterial,venous thrombosis and pregnancy associated morbidity *miscarriages)
|
|
anti-smooth muscle antibodies:
|
type 1 autoimmune hepatitis (slowly progressing)
|
|
anti liver kidney microsomal antibodies:
|
type 2 autoimmunie hepatitis (can progress rapidly)
|
|
anti-mitrochonidrial antibody:
|
primary billiary cirrhosis
|
|
anti gastric parietal cell ab:
|
pernicious anaemia/atrophic gastritis
|
|
anti-intrinsic factor ab:
|
pernicious anaemia (check B12)
|
|
anti-endomsial antibodies:
|
celiacs
|
|
reduced C3, C4
|
active lupus
|