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7 Cards in this Set
- Front
- Back
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Tetanus enzymatically destroys what protein? |
Synaptibrevin in pre-synaptic neurons |
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What neurotransmitter's release is limited by tetanus? |
Glycine |
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Tetanus travels in what route? |
Up motor axons to spinal cord's anterior horn, then across the presynaptic terminals of synapses between Renshaw cells and motor neurons, where Tetanus toxin enzymatically destroys synaptobrevin, disabling synaptic release of glycine, a critical inhibitory neurotransmitter. |
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Botox interferes with NM transmission via what mechanism? |
Botulinum toxin A, C, E enzymatically cleave SNAP-25. Botox B, D, E, F (and tetanus toxin) target synaptobrevin. Damage to these SNARE proteins result in impaired vehicle release. |
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Organophosphates impair NM transmission via what mechanism? |
Impaired function of acetylcholinesterase |
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Organophosphate poisoning symptoms-- organized by nicotinic versus muscarinic receptor symptoms. |
Nicotinic: weakness Muscarinic: confusion, constructed pupils, urinary incontinence, sweating |
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Adult botulism tx |
Within 24 hours, consider equine serum heptavalent botulism antitoxin. After 24 hrs, supportive care. |
