term1 Definition1term2 Definition2term3 Definition3
Please sign in to your Google account to access your documents:
ALPS
- Non-SCID
- FAS/FASL deficiency
(PKC delta, caspase 10, gof-NRAS/KRAS, CTLA4, FADD [adapter protein])
- Inability to apoptose effctor CD8 tcells after activation (and to a lesser extent activated B cells)
- Flow: Increased CD3+4-/8- TCRab+ (^B/Ig's)
- Uncontrolled lymphocyte proliferation
- Splenomegaly/Lympadenopathy (*enlarged follicles and increase blast cells).
-Autoimmunity towards cells.
- Increased IL-10,-IL-18, FASL, B12
- TUNEL Assay: Incubate lymphocytes then ADD FAS analogue, shoulder be the majority apoptosing (not single digits).
- Treat with long steroid taper
- Malignancy surveillance
Tes
Test
a
Need help typing ? See our FAQ (opens in new window)
Please sign in to create this set. We'll bring you back here when you are done.
Discard Changes Sign in
Please sign in to add to folders.
Sign in
Don't have an account? Sign Up »
You have created 2 folders. Please upgrade to Cram Premium to create hundreds of folders!