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Reasons for neuropathy
Physical trauma
Systemic disease i.e. diabetes
Nutritional deficiency i.e. vit b12
Blood supply obstruction i.e. vasculitis, arteriosclerosis
Infection i.e. HIV
Side effects of certain anti cancer drugs
Types of nerve injury
Neuropraxia (disruption of blood supply due to compression)
Axonotmesis (axon itself is disrupted,wallerian degeneration)
Neuronotmesis(neuron and sorrounding tissue)
Ascending order of increasing severity
Nerve regeneration
Injury signal promote RAG (regeneration associated gene)
Dedifferentiation of Schwann cells promote (NGF) neurogenic growth factor
Schwann cells and macrophage release (TGF BETA) transforming growth factor
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