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How does Na/KATPase work?
Transporter has high affinity for Na+ ions inside cell, 3 Na+ ions bind to binding sites, transporter hydrolyses ATP and becomes phosphorylated, conformational change occurs, affinity for Na+ decreases so they are released, affinity for K+ ions inceases, 2 K+ions binf to binding sites, transporter becomes dephophorylated, conformational change occurs, affinity for K+ decreases and they are released inside the cell
What is Na/KATPase used for?
Maintaining osmotic balance in animal cells, maintaining and generating ion gradients for resting potential in neaurons, generating ion gradient in kidney tubules, and generating ion gradient for glucose symport
What is resting potential?
Imbalance in electrical charge across the membrane of a neuron
What is nerve transmission?
A wave of depolarisation of the resting potential
How is depolarisation of the resting potential triggered?
Neurotransmitter binds to receptor protein, ligand gated channel opens so Na+ ions diffuse into neuron, sufficient Na+ movement causes depolarisation, critical level of depolarisation is reched, voltage gated channel to open to diffuse neuron
How is resting potential reset?
Na+ voltage gated channels close, voltage gated K+ channels open, K+ ions diffuse in opposite direction, once resting potential is reached, K+ channel closes again
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