term1 Definition1term2 Definition2term3 Definition3
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IP3: Inositol-1,4,5-triophosphate
1) Ligand binds
2) G alpha S activated exchanging GDP - GTP
3) Adenyl cyclase is activated converting ATP to CAMP
4) PKA is activated: Has 4 subunits (2 regulatory which bind to AMP and 2 catalytic which phosphorylates the target)
- ADP ribolysation prevents the G alpha S from hydrolysing the GTP thus it is permanently on and stimulating adenylyl cyclase causing elevated levels of CAMP.
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