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relative risk ratio eqn
risk of disease in relatives of type R/risk of disease in general population
what is the cut off for a RRR
anything greater than 1 suggests a familial component
RRR is a measure of the strength of
familial aggregation
pairwise concordance equation
# both affected / # both affected + # one affected
what is an example of a complex disease with regard to twin concordance
early-onset parkinsons has much higher concordance amongst MZs than late-onset parkinsons
a parent-offspring regression can be used to measure
hertability
how many mating types will there be with a bi-allelic locus?
6
equation for segregation ratio
affected offspring/total offspring
use segregation analysis to look for
major gene or inheritance pattern
linkage analysis is generally done after what other kind of analysis
segregation analysis
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