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What drugs affect protein synthesis
Aminoglycosides
Tetracyclines
Macrolides
Chloramphenicol
*Gentamicin - Trade name: Genoptic, Garamycin
*Tobramycin - Trade name: Tobrex
*Neomycin
*Amikacin
Composed of a sugar group and an amino group
MOA of Aminoglycosides
Binding to the 30S subunit of the bacterial ribosome leads to inhibition of protein synthesis and incorrect reading of genetic code
b/c against broad spectrum of bacteria including S. aureus and many strains of Gram - bacteria including P. aeruginosa, Proteus, Klebsiella, E.coli, Enterobacter, and Serratia
What group shows wide spread resistance to Aminoglycosides because they may produce different amino glycoside-inactivating enzymes
Gram negative bacilli
Synergistic effects of Aminoglycosides
Additive or synergistic effect against most aerobic Gram negative bacilli and Gram positive cocci when combined with Beta-lactam A/bs
Synergistic effect against Gram-positive cocci when combined with vancomycin
Inactive against anaerobes and poorly active against streptococci, enterococci and MR S. aureus
How are Aminoglycosides derived?
From bacteria Streptomyces (-mycin)
and
Micomonospora (-micin) genus
If used systemically, how does Aminoglycosides need to be administered?
Poorly absurd from the GU tract so when used systemically must be given parenterally
_____________ and ____________ can inactivate amino glycosides if mixed in same solution for injection or topical application
PCNs or Cephalosporins
Each drug must be administered separately; if topical fortified cefazolin and fortified tobramycin are used to tx a corneal ulcer, each should be prepared and administered in separate bottle
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