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Describe abnormal periorbital ECM / thyroid disease (exopthalmos)
Characterized by a swollen thyroid gland and defect in the fibroblasts of the eye
The decomposition of glycosaminoglycans and the influx of water increase the orbital contents
Describe Marfan syndrome
Characterized by long limbs
Caused by a defect in a mutation for gene 15, which codes for fibrillin. Fibrillin is a glycoprotein that contributes to the growth of elastin, resulting in the body producing more Transforming Growth Factor beta
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