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MOA of H1 Anti-histamines
Block H1 receptors especially in Mast Cells
Mast Cells
Clinical Uses of H1 Anti-histamines
-allergic rhinitis
-allergic contact dermatitis
H1 receptor stimulation leads to:
-Extravascular smooth muscle contraction
-Vascular smooth muscle relaxation
-Endothelial cell contraction
-ESM & EC contraction
-VSM relaxation
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