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Which special properties does diclofenac have over other NSAIDs?
It accumulates in synovial fluid, possibly making it more useful in treating joint pain.
It also has higher cardiovascular risk.
Which special properties does indomethacin have over other NSAIDs?
It inhibits phagocytosis of urate crystals, possibly making it more useful in treating gout.
Which NSAIDs has less cardiovascular risk than other NSAIDs?
Naproxen, ibuprofen
Name some COX2-preferential NSAIDs
Celecoxib, paracetamol, meloxicam
Name some COX2-specific NSAIDs
Parecoxib, etoricoxib
In what cases are COX2-selective NSAIDs preferred over non-selective NSAIDs?
- Peptic ulcer
- Platelet disorders
- Aspirin asthma
- Familial adenomatius polyposis
Which NSAID has the highest cardiovascular risk?
Diclofenac
What are the contraindications for coxibs?
Sulpha allergy
What are the side effects of COX2-selective NSAIDs?
Decreased renal function
Cardiovascular side effects
Which side effects do COX2-selective NSAIDs lack compared to non-selective ones?
COX2-selective NSAIDs have:
- No antiplatelet effect
- Minimal GI side effects
- No aspirin asthma
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