term1 Definition1term2 Definition2term3 Definition3
Please sign in to your Google account to access your documents:
Why don't peptides work well as drugs?
- They're hydrolysed in the intestines
- They're difficult to manufacture
- They're hydrolysed in plasma
- They don't penetrate the blood brain barrier
- They may be immunogenic
What is the mechanism of action and indication of icatibant?
Icatibant is a bradykinin B2 antagonist used to treat angioedema
Bradykinin is important in the development of a certain side effect of a certain type of drug. Which drug and what is the side effect?
Accumulation of bradykinin during ACE inhibitor treatment causes dry cough as a side effect.
Name two drugs which act on tachykinin receptors and their indications.
Aprepitant and netupitant are NK1-receptor antagonists and have anti-emetic effect.
What are the name and indications of somatostatin analogues?
Somatostatin analogues like octreotide are used to treat cancers that secrete any of the hormones that are inhibited by somatostatin. They’re also used to treat acromegaly, a condition characterised by too much growth hormone.
Name some drugs which act on the purinergic system and which receptors they act on.
Theophylline, caffeine - antagonizes adenosine receptors
Clopidogrel, prasugrel and ticlopidine - antagonize P2Y12 receptors.
What are the indications for P2Y12 antagonists?
Antiplatelet therapy
Theophylline - COPD, asthma
Caffeine - medical students
NO is produced by arginine by the enzyme nitric oxide synthase (NOS)
Three forms of NOS exist: endothelial NOS, neuronal NOS, inducible NOS
What is the function of endothelial NOS?
Endothelial NO synthase is found in the endothelium and produces NO for use as a vasodilator
Need help typing ? See our FAQ (opens in new window)
Please sign in to create this set. We'll bring you back here when you are done.
Discard Changes Sign in
Please sign in to add to folders.
Sign in
Don't have an account? Sign Up »
You have created 2 folders. Please upgrade to Cram Premium to create hundreds of folders!