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24 Cards in this Set
- Front
- Back
Functions of CT
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-structural support
-medium for exchange -defense/protection |
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What's CT made of
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-extracell matrix:
ground subst.,extracell fibers,tissue fluid -Cells |
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2 types of CT
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Loose connective/dense connective
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LCT
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-made of fibers=reticular/collagen/elastic
-ground subst=for H2O diffusion,O2,CO2, nutrients -lots of cells: fibroblasts/macrophage/leuko/adipose/mast |
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DCT
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-made of dense fibers
-has fibrobblasts -makes=tendons/ligaments/aponeuroses (all have coll type 1) |
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Collagen
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-most abundant
-flexible -stains pink w/ eosin dye -fiber->fibrile->collagen |
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Type 1 collagen
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in fibriles,fibers,bundles
-dentin -tendons -ligaments -bone |
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Type 2
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just fibriles
-elastic cartilage -hyaline cartilage |
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Type 3
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fibriles & reticular fibers
-lymph -spleen -organs |
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Type 4
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filaments
-BL |
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Type 5
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-placenta
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Coll synth.
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in RER:
preprocoll->signal cut->procoll->hydroxylation by proline & lysine residues->now its glycosylated & procol forms trip helix-> exported out of golgi->tropocoll 2 alpha,alpha & 1 alpha 2 chain |
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Reticular fibers
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-support & framework for tissues & organs
-type 3 -in nerves/bv's/muscle/lymph/rd bone marrow/endocrine glnds |
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Elastic fibers
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-elastisity
-in EC matrix -made of proteoglycans & glycoprots (rich in pro &gly) -in LCT/aorta/ligamentum flavae |
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Ground Substance
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-allows for diff of nutrients & O2
-inc H2O content made of: proteoglycans that are made from GAG,& glycoprots these form polycacc chains |
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What does GAG do?
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-sulfation of sugar residues->causes charge->allows basic dye stains->attracts H2O->hydrates gel->allows diff of H2O & sol subts
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7 types of GAG's
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based on degree of sulfation & type of sugar residue
-2 chondrotins -2 heparans -1 hydronic acid -1 keratin -1 dermatin |
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Fibroblast cells
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-fixed
-makes & destroys collagen,grnd subst.,elastic & retic fibers -2 forms inactive & active active= in cytoplasm,lots of it,lots of RER,irreg branched inactive= small,spindle shape,les RER |
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Macrophage
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-fixed
-from monocytes -diapedesis -have lysosomes/lots of RER/big golgi/lots of MT's & MF's function: -phago/pino -activate imm sys. -resist inf. |
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Mast cell
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-from BM
-cyto plasm has lots of granules is metachromatic release: heparin-anticoag histamine-vasodil leukotriene-slow cont of sm. musc. |
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Immediate hypersensitivity rxns
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after 1st exp. to Ag->IgE binds to its recept. on mast cell=sensitization
-after 2nd exp->same Ag binds to IgE on mast cell->degranulation->releases->histamine,leukotrines |
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Plasma cells
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make Abs to certain Ags
migrate to CT when infect. |
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Mesenchyme
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-makes lots of cells
-makes myofibroblasts for wound repair |
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Adipose
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brown-fetal gone after 10 yoa,multilocular
white-unilocular -provides energy -insulates -lots of retic fibers & bld vessels |