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7 Cards in this Set
- Front
- Back
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Common Themes: Giardia lamblia, Entamoeba histolytica, & Trichomonas vaginalis
-Aerobic or Anaerobic? -Do they have Mitochondria? -General description of pathogenesis & drug used against them |
-Facultative Anaerobes; carbohydrate metabolism is anaerobic
-Lack mitochondria -Extracellular Parasites – Lumen dwelling; Do not invade host cells; Adhere to PM of host cells; Contact dependent cytotoxicity; Mechanical damage to host cells; Replicate & divide w/in the host by binary fission; Can be cultivated in axenic cultures in the laboratory; All killed by metronidazole (flaglyl) – a drug that selectively kills anaerobic cells |
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Giardia lamblia & Entamoeba histolytica
Describe the basic life cycle |
*Transmission from Host to Host by Resistant Cyst
Fecal-Oral-Route – Ingestion of Cysts Contaminating Water or Food Person-to-Person Route – homosexuals, institutions (daycare centers) *Intestinal Colonization of Human Host -Excysted, motile trophozoite colonizes intestines -Feeding/Growing trophozoite causes disease |
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Giardia lamblia
Excystation site? Nutrient source? Attachment? Colonization site? |
G. lamblia:
Excystation site: Triggered by gastric acid Nutrient source: Absorbs from host Attachment: Adhesive disc Colonization site: Small intestine |
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Entamoeba histolytica
Excystation site? Nutrient source? Attachment? Colonization site? |
Entamoeba histolytica
Excystation site: Lower small intestines Nutrient source: Phagocytic, Phagocytosis of RBC’s, tissue bacteria Attachment: Lectins Colonization site: brain Large bowel lumen, May invade mucosa, liver, & brain |
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G. lamblia
Morphology? Life Stages? Host? Transmission? Disease Manifestation? |
G. lamblia
Morphology: Flagellate Life Stages: Trophozoite, Resistant Cyst Host: Many Mammals Including Humans Transmission: Ingestion of Cyst Disease Manifestation: Diarrhea, Dysentery |
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E. histolytica
Morphology? Life Stages? Host? Transmission? Disease Manifestation? |
E. histolytica
Morphology: Amoeba Life Stages: Trophozoite, Resistant Cyst Host: Human only Transmission: Ingestion of Cyst Disease Manifestation: Diarrhea, Liver Absess |
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T. vaginalis
Morphology? Life Stages? Host? Transmission? Disease Manifestation? |
T. vaginalis
Morphology: Flagellate/Amoeba Life Stages: Trophozoite Only, No Cyst Form Host: Humans Only Transmission: Sexual Intercourse Disease Manifestation: Vaginitis, PROM |
