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B and T cell Acute lymphoblastic leukemia

11q23 abnormalities


9p abnormalities (9p21 most common)

9p has CDKN2A and 2b tumor suppressor genes

T cell Acute lymphoblastic leukemia only

14q11 rearrangements

Chronic lymphoblastic leukemia

B cell +12, del(13q), del(11q) ATM, del(17p) p53, rea(14q32) IGH



T cell inv(14)(q11q32)

Multiple myeloma

Del(13), rea(14)(q32), del(17p)


+3/5/7/9/15/19

Low mitotic index, FISH plasma only