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77 Cards in this Set
- Front
- Back
products of ----
|
streptomyces
too toxic to use as abx |
|
daunorubicin, doxorubicin, idarubicin
|
hematological and solid tumors
|
|
bleomycin:
|
testicular
head neck cervical hodgkin's lymphoma and sarcomas |
|
dactinomycin tx
|
ewings sarcoma
wilm's tumor |
|
plicamycin
|
testicular
|
|
plicamycin tx
|
testicular ca
|
|
mitomycin tx
|
stomach
pancreas lung |
|
moa of abx's
directly bind to ---- or -- btw dna bps preventing dna ----- |
dna
intercalate replicaton |
|
dactinomycin
--- dna -- strand breaks |
intercalates
single |
|
t/f
dactinomycin is cell specific |
f
not cell specific |
|
dactinomycin
one of the ---- tumor agents |
potent
also one of the most toxic |
|
dactinomycin used for
|
rhabdomyosarcoma
wilm's tumor in kids |
|
tox of dactinomycin
---penia ---ia --- ----- ---cia --- effects |
pancytopenia
anorexia n/v alopecia gi effects |
|
how do daurubicin and doxorubicin differ
|
by OH group
|
|
daurubicin and doxorubicin
intercalate into dna prevent ------ inhibits ------ |
prevents uncoiling
inhibits topoisomerase 2 (repairs strand breaks) |
|
preventing topoisomerase will prevent
|
uncoiling of dna for copying
|
|
daurubicin and doxorubicin
bind to cell ----- alters --- activation |
membrane
IP3 |
|
daurubicin and doxorubicin
may be --- toxic |
cardiotoxic
lifelimit on both meds |
|
daurubicin and doxorubicin originally obtained from
|
stretococcus peucetius caesius
|
|
daurubicin and doxorubicin
metabolism forms --- ---- which forms --- ---- |
semiquinone intermediate
free radicals |
|
daurubicin and doxorubicin
interacts w/ dna to cause ---- --- and --- ---- |
dna damage
strand breaks |
|
daurubicin and doxorubicin
inhibit dna ----- and ---- -- |
polymerase
topoisomerase 2 |
|
what enzyme scavengers free radicals
|
superoxide dismutase . .. so a deficiency will lead to more free radicals
|
|
what tissues are low in superoxide dismutase
|
tumors
cardiac tissue |
|
what combines two free radicals to creaste H2O2 and catalase
converts H2O2 to H2O |
superoxide catalase
|
|
what tissue is low in superoxide catalase
|
cardiac tissue
|
|
daurubicin and doxorubicin forms free radicals
cardiac tissue low in superoxide dismutase and catalase what can occur |
cardiotoxicity
|
|
daurubicin and doxorubicin route
|
I
|
|
t/f
daurubicin and doxorubicin cell specific |
f
not cell specific |
|
daurubicin used to tx
|
acute myelogenous leukemia
|
|
danoxome liposomal prep used to tx
|
kaposi sarcoma
|
|
which has a wider use
daurubicin or doxorubicin |
doxorubicin:
breast bladder lung ovarian testicular thyroid all hodgkin nonhodgkin sarcoma neuroblastoma |
|
tox of daurubicin and doxorubicin
moderate --- --- ---supprssion --- tox discoloration of ------ |
n/v
myelosuppression cardiac toxicity discoloration of urine |
|
daurubicin and doxorubicin
cardiac toxicity: r/t |
cumulative dose
myocardial cell damage heart failure |
|
daurubicin and doxorubicin
what is used as a chelator and prevents free radicals |
dexrazoxane-Fe
|
|
--- complexes not taken up into heart cells
|
lipid
|
|
what color does urine turn w/ daurubicin and doxorubicin
|
red
|
|
daurubicin and doxorubicin tox
---- ulcerations -- disturbances ---cia severe --- properties severe --- and ---- of tissue |
mucosal
gi disturbances alopecia severe vesicant properties severe ulcerations and necrosis of tissue |
|
daurubicin and doxorubicin tox
--- leukemias ---genic |
secondary leukemias
teratogenic |
|
doxorubicin = -----
part of the --- regimen for hodgkin's |
adramycin
ABVD |
|
idarubicin, epirubicin, valrubicin are non cell specific/ cell specific
|
non cell specific
|
|
idarubicin used to tx
|
aml
all cml |
|
idarubicin is
more/less cardiotoxic more/less mucosititis |
less cardiotoxic
more mucosititis |
|
daurubicin and doxorubicin
discolors the urine ___ |
red
|
|
daurubicin and doxorubicin
---genic |
teratogenic
|
|
epirubicin used to tx
|
bladder
head neck breast lung ovarian severe n/v |
|
epirubicin can cause --- toxicity
---genic |
cardiotoxicity
teratogenic |
|
t/f
epirubicin will discolor urine red |
t
|
|
valrubicin used to tx
|
bladder tumors
|
|
se of valrubicin
|
red urine
teratogenic |
|
mitoxantrone used to tx:
|
aml
cll breast ovarian |
|
mitoxantrone more/less cardiotoxic
|
less
|
|
mitoxantrone causes ---- -----
----cia --- toxicity --- dysfunction |
bone marrow suppression
alopecia hepatic toxicity sexual dysfunction |
|
color of mitoxantrone injection
|
blue
|
|
mitoxantrone discolors urine:
|
blue-green
|
|
mitoxantrone nail color
|
blue
|
|
t/f
mitoxantrone has the same vesicant properties |
f
|
|
mitoxantrone also used in progressive, relapsing, ---
|
MS
multiple sclerosis |
|
bleomycin from the
|
stretpmyces verticillus
|
|
bleomycin is a mixture of -- and ---
|
A2
B2 |
|
bleomycin
-- ring structure can --- w/ dna |
flat
intercalate |
|
bleomycin
metal binding core complexes w/ -- and --- |
Fe
Cu (stimulate free radical formation) |
|
bleomycin
in presence of O2 metal complexes produces --- ---- breaks DNA, --- ----- |
free radicals
lipid peroxidation |
|
bleomycin
cell specific? |
yes
|
|
bleomycin
specific for -- phase |
G2
|
|
bleomycin used to tx
|
cervical
head/neck pancreatic testicular ovarian hodgkin's nonhodgkin's sarcoma bladder |
|
bleomycin
part of the -- regimen |
ABVD
|
|
ABVD regimne
|
adriamycin
bleomycin vinblastin darcarbazine |
|
tox of bleomycin
low ----- ---genic dry ----- can lead to --- ----- |
low myelosuppression
teratogenic dry cough pulmonay fibrosis |
|
bleomycin tox
--- and ---- mild -- and ---- ---ia |
fever and chills
n/v alopecia |
|
bleomycin tox
---- ulceration ---rxns hyper------ --- of skin |
mucosal
skin rxns hyperpigmentation blistering of skin |
|
mitomycin from
|
streptomyces casepitosis
|
|
mitomycin
---tion forms ----- ---- --- breaks |
alkylation
free radicals chromosal breaks |
|
mitomycin
soln color |
blue-grey
|
|
mitomycin txs
|
head/neck
breast colon soft tissue sarcoma mestatic bone stomach lung bladder |
|
mitomycin tox:
cumulative severe --- ---- wait -- weeks btw txs |
bone marrow suppression
wait 8 weeks |
|
mitomycin tox
-- tox ---ia secondary ------ |
pulmonary toxicities
alopecia secondary leukemia's |