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19 Cards in this Set
- Front
- Back
What are Coagulopathies?
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deficiencies in one or more components that regulate hemostasis.
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What are deficiencies in one or more components that regulate hemostasis?
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Coagulopathies
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What is immune thrombocytopenic purpura (ITP)?
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autoimmune destruction of platelets
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What is Thrombotic Thrombocytopenic Purpura (TTP)?
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rare disorder where platelets clump together inappropriately
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immune thrombocytopenic purpura ITP symptoms?
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-large bruises
-petichial rashes -bleeding gums -intracranial bleed -splenic sequestration (spleen holds 90% of cells vs. 30%) |
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thrombotic thrombocytopenic purpura (TTP) symptoms?
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-thrombocytopenia
-anemia -purpura (red/purple patches) -renal failure |
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What goes wrong with immune thrombocytopenic purpura (ITP)?
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normal # of platelets are made. IgG is made that directs toward platelets. the coating on platelets make them more susceptible. spleen attacks and lyses the platelets.
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What goes wrong with thrombotic thrombocytopenic purpura (TTP) symptoms?
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mechanism unknown. platelets clump together which keeps them out of the normal circulation. platelets are unable to respond to injury.
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What is Disseminated Intravascular Coagulation (DIC)?
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clotting/bleeding happen simultaneously
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What are some causes of Disseminated Intravascular Coagulation (DIC)?
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-gram negative sepsis
-hypoxia -acidosis -cardiopulmonary arrest -burns -complications of pregnancy -malignancy |
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Clinical features of Disseminated Intravascular Coagulation (DIC):
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-sudden onset of bleeding (every orifice)
-thrombi causes multiple infarcts -increased PT/PTT -increased fibrin degradation products (FDP) |
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What do increased Prothrombin time (PT)/Partial thromboplastin time (PTT) levels tell us with DIC?
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it will take longer for pt. blood to clot
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PT/PTT test what?
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pt. ability to clot
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PPT test?
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assesses intrinsic pathway
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PT test?
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assesses extrinsic pathway
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What do increased FDP levels tell us with Disseminated Intravascular Coagulation (DIC)?
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there is increased fibrinolysis
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Hemophilia A, B (Christmas disease):
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Hemophilia A: classic hemophilia. typically missing clotting factor VIII.
Hemophilia B: missing clotting factor IX |
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Who shows the trait for the Hemophilias?
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X linked clotting disorder. only affecting males. women can be carriers
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Why do these patients bleed with Hemophilias?
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platelet plugs cannot form, inhibiting clotting. affects the intrinsic pathway
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