Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
23 Cards in this Set
- Front
- Back
|
What are blood cells made up of |
Endothelial cells |
|
|
What happens if a blood cell get hurt |
Endothelial cells open |
|
|
What happens first in the injured blood cell |
Platelets form a plug |
|
|
How is fibrin moving around the blood |
Move around as finrinogen. |
|
|
Function of fibrinogen |
Covers one active site of fibrin to stop it stick to each other at random in the body |
|
|
What converts fibrinogen to fibrin at site of injury |
Thrombin |
|
|
What activates thrombin |
The prothrombin on one of its active sites |
|
|
What is thrombin in the coagulation cascade |
2 |
|
|
What is fibrin in the coagulation cascade |
1 |
|
|
Order of the intrinsic pathway |
XII-XI-IX(+IIX)-X(+V)-II-1 |
|
|
Order of extrinsic pathway |
III (TF)- VII- X |
|
|
What clotting factors does thrombin activate |
5 7 8 11 13 |
|
|
Which clotting factor ensures fibrin forms a tight mesh |
13 |
|
|
What are the negitve feedback loops involved to stop over clotting |
Creates plasminogen (convertsit to plasmin) and antithrombin |
|
|
What does plasmin do |
Acts on fibrin strands in clot and breaks them apart |
|
|
Function of antithrombin |
Reduced production of thrombin from prothrombin and stops activation of clotting factor X |
|
|
What are the 3 types of heamophilia |
A b c |
|
|
What causes heamophilia A |
Deficiency in clotting factor VII |
|
|
What causes heamophilia B |
Deficiency in clotting factor IX |
|
|
What causes heamophilia C |
Deficiency in clotting factor XI |
|
|
What activates factor X on the intrinsic pathway |
Factor XIIIa and IX and Ca++ |
|
|
What activates factor X on the extrinsic pathway |
Factors IIIa and VIIa and Ca++ |
|
|
What is factor IV |
Ca++ |
