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39 Cards in this Set
- Front
- Back
What is the most common type of anxiety disorder?
Specific phobia, GAD, PD, or SAd? |
Specific phobia is the most common form of anxiety disorder (8.7%)
Followed by SAD (6.8%), GAD (3.1%), PD (2.7%) |
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Which key brain feature is responsible for assessment of fear & learned response to fear?
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Amygdala (temporal lobe)
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Which key brain feature is responsible for fear response?
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Locus ceruleus (brain stem)
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What key brain feature is responsible for consolidation of traumatic memory & fear conditioning?
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Hippocampus
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What key brain feature is repsonsible for neuroendocrine & autonomic response to a threat?
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Hypothalamus
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_____ is effective for Generalized Anxiety Disorder (GAD), but not Panic Disorder (PD).
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Buspirone
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Term for "anxiety about being in places or situations where escape is difficult".
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Agoraphobia
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First-line treatment for Generalized Anixiety Disorder (GAD) includes: ______, ______, _______, & ______.
(*hint: 4 drugs...) |
First-line treatment for Generalized Anixiety Disorder (GAD) includes:
Duloxetine (Cymbalta) - SNRI Escitalopram (Lexapro) - SSRI Paroxetine (Paxil) - SSRI Venlafaxine XR (Effexor XR) - SNRI |
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Second-line treatment for Generalized Anxiety Disoder (GAD) includes: ______, ______, _______, & ______.
(*hint: 1 class & 3 drugs...) |
Second-line treatment for Generalized Anxiety Disoder (GAD) includes:
Benzodiazepines Buspirone (Buspar) Imipramine (Tofranil) - TCA Sertraline (Zoloft) - SSRI |
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First-line treatment for Panic Disorder (PD): ____ & ____
(*hint: 1 class & 1 drug) |
SSRI's
Venlafaxine XR (Effexor XR) - SNRI |
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Second-line treatment for Panic Disorder (PD): ____, ____, ____, & ____
(*hint: 4 drugs....) |
Second-line treatment for Panic Disorder (PD):
Alprazolam (Xanax) - BZD Clomipramine (Anafranil) - TCA Clonazepam (Klonopin) - BZD Imipramine (Tofranil) - TCA |
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First-line treatment for Social Anxiety Disorder (SAD): ____, ____, ____, & ____
(*hint: 4 drugs...) |
First-line treatment for Social Anxiety Disorder (SAD):
Escitalopram (Lexapro) - SSRI Fluvoxamine (Luvox) - SSRI Sertraline (Zoloft) - SSRI Venlafaxine XR (Effexor XR) - SNRI |
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Second-line treatment for Social Anxiety Disorder (SAD): ___ & ___
(*hint: 2 drugs...) |
Citalopram (Celexa) - SSRI
Clonazepam (Klonopin) - BZD |
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BZD: ____ is a prodrug - converted in liver
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Clorazepate (Tranxene)
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BZD: ____ & _____ bypass phase 1 oxidation --> less likely to have PK interactions
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Lorazepam (Ativan) & Oxazepam (Serax)
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Approved dosage range (mg/day) of Alprazolam (Xanax)?
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0.75 - 4
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Approved dosage range (mg/day) of Chlordiazepoxide (Librium)?
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Approved dosage range (mg/day) of Chlordiazepoxide (Librium)?
15 - 100 |
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Approved dosage range (mg/day) of Clonazepam (Klonopin)?
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Approved dosage range (mg/day) of Clonazepam (Klonopin)?
1 - 4 |
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Approved dosage range (mg/day) of Clorazepate (Tranxene)?
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Approved dosage range (mg/day) of Clorazepate (Tranxene)?
7.5 - 60 |
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Approved dosage range (mg/day) of Diazepam (Valium)?
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Approved dosage range (mg/day) of Diazepam (Valium)?
2 - 40 |
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Approved dosage range (mg/day) of Lorazepam (Ativan)?
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Approved dosage range (mg/day) of Lorazepam (Ativan)?
0.5 - 10 |
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Approved dosage range (mg/day) of Oxazepam (Serax)?
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Approved dosage range (mg/day) of Oxazepam (Serax)?
30 - 120 |
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Generalized Anxiety Disorder: ___ are preferred agents for pregnant patients.
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Antidepressants (SSRI's & TCA's)
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___ is FDA approved for Panic Disorder (PD) with or without agoraphobia.
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Alprazolam (Xanax)
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BZD bind to GABA-A alpha-2 subunit --> anxiolytic/sedation effect?
BZD bind to GABA-a alpha-1 subunit --> anxiolytic/sedation effect? |
alpha-2 --> anxiolytic
alpha-1 --> sedation |
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BZD pharmacokinetics:
___ & ___ are less lipophilic & have a slower absorption time |
Lorazepam (Ativan) & Oxazepam (Serax)
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BZD pharmacokinetics:
IM administration of ___ & ___ should be AVOIDED - erratic absorption & painful |
diazepam (Valium) & chlordiazepoxide (Librium)
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BZD PK:
___ (drug) undergoes nitroreduction |
clonazepam (Klonopin) undergoes nitroreduction
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BZD PK:
Diazepam is also metabolized by ____ (in addition to CYP 3A4) |
CYP 2C19
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BZD PK:
Long acting drugs, like ____ & ___, are metabolized to DMDZ (active metabolite) |
clordiazepoxide (Librium)
diazepam (Valium) |
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BZD PK:
___ is a prodrug converted to DMDZ in the GI tract under acidic pH (Don't take with antacids!) |
clorazepate (Tranxene)
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Panic Disorder (PD)
What is the maintenance Tx time? |
12 to 24 months
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___ (drug class) & ___ (drug) are NOT effective in SAD.
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TCA's & Fluoxetine
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PTSD: ____ (drug class) are first-line agents.
___ & ___ (drugs) are FDA approved for acute treatment |
SSRIs
Sertraline & Paroxetine |
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PTSD: ____ was NOT effective!
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Buproprion
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PTSD: Maintenece Tx for at least ___ months.
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12 months
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5 FDA approved drugs for treatment of OCD?
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5 FDA approved drugs for treatment of OCD:
clomipramine fluvoxamine fluoxetine paroxetine sertraline |
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Which drug class is the first-line treatment for OCD?
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SSRI's
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Therapy for OCD should last how long?
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1 to 2 years
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