Cmbm- Exam 4- Angiogenesis

Front 1

Endothelial cell precursors that establish the primitive vascular network

Back 1

Angioblasts

Front 2

Cell that links hematopoietic and vascular systems and embryonic vascular systems during embryonic development

Back 2

Hemangioblast

*Produce hematopoietic stem cells and angioblasts

Front 3

Cell that proliferates and migrates to peripheral sites and differentiate into endothelial cells that form arteries, veins and lymphatics, pericytes and smooth muscle cells

Back 3

Angioblasts

Front 4

Growth factor that increases vascular permeability, stimulates endothelial cell precursors from bone marrow, and increases proliferation of the cells at the site of angiogenesis

Back 4

VEGF

*come from endothelium and macrophage

Front 5

Growth factor that enhances endothelial proliferation, differentiation, and migration

Back 5

FGF-2

*come from endothelium, macrophage and fibroblast

Front 6

Cytokine that recruits smooth muscle cells

Back 6

PDGF

*come from platelet, monocyte, smooth muscle cell, and macrophage

Front 7

The moment at which a tumor begins to over express pro-angiogenic factors such as VEGF

Back 7

Angiogenic Switch

Front 8

Angioblast like cells stored in adult bone marrow

Back 8

Endothelial precursor cells

Front 9

Receptor which stimulates the proliferation of endothelial cells and endothelial precursor cells within the bone marrow

Back 9

VEGFR-2

*also increases vascular permeability

Front 10

Destabilize cell matrix interactions and promote angiogenesis

Back 10

Matricellular proteins

Front 11

Remodel tissues during endothelial invasion and release VEGF and FDF-2

Back 11

Proteinases

*plasminogen activator and metalloproteinases