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29 Cards in this Set
- Front
- Back
Can move through Epithelium
Can Polymerize to Dimer
Tears, Saliva, Vagina, Mucus |
IgA |
|
Can polymerize to Pentamer |
IgM |
|
Only 2 non-monomers |
IgA
IgM |
|
Immunologic Memmory |
IgG |
|
What 2 provide neutralization? |
IgG
IgA |
|
Which one provides Opsonization |
IgG |
|
Which one is sensitive to Mast cells |
IgE |
|
Which 2 are involved in activation of complement |
IgM and IgG |
|
First Antibody to be secreted * |
IgM |
|
Activates complement via classical cascade |
IgM |
|
How does a humoral immune response proceed via class switching? |
B cells undergo somatic hypermutation:
"mutation that occurs at high frequency in the rearranged variable region DNA of immunoglobulin genes in activated B cells, resulting in the production of variant antibodies, some of which have a higher affinity for the antigen"
IgM declines
IgG and IgA produced |
|
What are the 4 functions of IgG? |
Precipitation
Agglutination
Complement Fixation
Neutralization |
|
Describe Agglutination |
Clumping in petri dish due to positive result/antibody present.
IgG |
|
Found in breast milk |
IgA |
|
Protects mucosal surfaces |
IgA |
|
Describe IgA secretory function |
Secreted on luminal side with a remnant of the poly-Ig receptor called secretory component*
Secretory component binds mucins, which keeps IgA bound microbes from attaching to epithelia |
|
Provides a mechanism for the rapid ejection of pathogens from the body |
IgE |
|
Parasites |
IgE |
|
Little circulates in Plasma |
IgE |
|
Sneezing, vomiting, diarrhea |
IgE |
|
Allergies and Asthma |
IgE |
|
Which Ig has trouble crossing endothelium because of its large size?
Which 2 can move through tissues? |
IgM
IgA and IgG can move through because are monomers |
|
Crosses placenta |
IgG |
|
What quantitative test for Antibodies gives quantitative results? |
ELISA |
|
What kind of titer is taken while illness present |
Acute Titer |
|
What kind of titer is taken after symptoms subside? |
Convalescent Titer |
|
Means primary response |
IgM---- first to arrive |
|
Means immune response |
IgG |
|
This test tells which antigens in the prep are on the entity the patient is making antibodies for |
Western Blot Analysis |