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4 Cards in this Set

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The 2 types of thrombi




Their differences: basics

Venous Thrombosis


Coagulation has major role, formation of major role


Arterial Thrombosis


Platelet aggregation has more important role
Coagulation also involved


Where the thrombi forms influences drug use

Venous Thrombosis




Coagulation has major role, formation of major role




Arterial Thrombosis




Platelet aggregation has more important role


Coagulation also involved




Where the thrombi forms influences drug use

Embolus

Fragment of thrombi detaches from vessel wall


Embolus travels through vessels, until in reaches a vessel too small to flow through


Blocks small vessel, forming embolism

Fragment of thrombi detaches from vessel wall




Embolus travels through vessels, until in reaches a vessel too small to flow through




Blocks small vessel, forming embolism

Aim of drug intervention for thrombi ?




Possible therapeutic uses?

Inhibit thrombus formation




without preventing normal haemostasis- bleeding out




Uses





  • Prevent heart attacks
  • Prevent strokes
  • Reduce damage after heart attack or stroke (latter fibrinolysis only)

Targets for modifying thrombosis process?

  • Modify coagulation : Most successful in venous thrombosis




  • modify platelet aggregation: Important in arterial thrombosis




  • Modify clot, thrombus formation: After prophylaxis fails