Clotting Drugs Basics

Front 1

The 2 types of thrombi

Their differences: basics

Back 1

Venous Thrombosis

Coagulation has major role, formation of major role

Arterial Thrombosis

Platelet aggregation has more important role

Coagulation also involved

Where the thrombi forms influences drug use

Front 2

Embolus

Back 2

Fragment of thrombi detaches from vessel wall

Embolus travels through vessels, until in reaches a vessel too small to flow through

Blocks small vessel, forming embolism

Front 3

Aim of drug intervention for thrombi ?

Possible therapeutic uses?

Back 3

Inhibit thrombus formation

without preventing normal haemostasis- bleeding out

Uses

• Prevent heart attacks
• Prevent strokes
• Reduce damage after heart attack or stroke (latter fibrinolysis only)

Front 4

Targets for modifying thrombosis process?

Back 4

• Modify coagulation : Most successful in venous thrombosis

• modify platelet aggregation: Important in arterial thrombosis

• Modify clot, thrombus formation: After prophylaxis fails