Clinical Chemistry - Chapter 13 - Enzymes

Front 1

Oxidoreductases

Back 1

oxidation-reduction reaction

Front 2

Transferases

Back 2

transfer of a group otherthan hydrogen from one substrate to another

Front 3

Hydrolases

Back 3

hydrolysis of various bonds

Front 4

Lyases

Back 4

removal of groupsfrom substrates without hydrolysis; product contains double bonds

Front 5

Isomerases

Back 5

interconversion ofgeometric, optical, or positional isomers

Front 6

Ligases

Back 6

joining of twosubstrate molecules, coupled with breaking of pyrophosphate bond in ATP

Front 7

Activation energy

Back 7

energy required to raiseall molecules in 1 mole of a compound at certain temperature to transitionstate at peak of energy barrier

Front 8

Enzymes catalyze reactions by lowering the _________________.

Back 8

activation energy

Front 9

In first-order kinetics, reaction rate is:

Back 9

directlyproportional to substrate concentration

Front 10

In zero-order kinetics, reaction rate:

Back 10

depends only on enzymeconcentration

Front 11

Enzymes are expressed in what units?

Back 11

IU/L

Front 12

Creatine Kinase is used to diagnose

Back 12

AMI, muscular dystrophy

Front 13

CK-MM is specific to:

Back 13

skeletal muscle

Front 14

CK-MB is specific to:

Back 14

heart

Front 15

CK-BB is specific to:

Back 15

brain

Front 16

Lactate Dehydrogenaseis used to diagnose:

Back 16

pernicious anemia, hemolytic disorders

Front 17

The Lactate Dehydrogenase isoenzyme most abundant in healthy individuals is:

Back 17

LD-2

Front 18

In cardiac necrosis, which Lactate Dehydrogenase isoenzyme concentration exceeds that of LD-2?

Back 18

LD-1

Front 19

AST is used in the diagnosis of:

Back 19

hepatocellular and skeletal muscle disorders,

Front 20

The AST assay is based on the:

Back 20

Karmen method

Front 21

The tissue source for ALT is:

Back 21

liver

Front 22

ALT is used in the diagnosis of:

Back 22

hepatic disorders

Front 23

ALP is used in the diagnosis of:

Back 23

hepatobiliary and bone disorders

Front 24

ACP is used in the:

Back 24

forensic investigation of rape

Front 25

GGT is used in the diagnosis of:

Back 25

hepatobiliary disorders, alcoholism

Front 26

Amylase is used in the diagnosis of:

Back 26

acute pancreatitis

Front 27

The tissue source for amylase is:

Back 27

pancreas and salivary glands

Front 28

The tissue source for lipase is:

Back 28

pancreas

Front 29

Lipase is used in the diagnosis of:

Back 29

pancreatitis, cholecystitis

Front 30

The tissue source of Glucose-6-PhosphateDehydrogenase is:

Back 30

erythrocytes

Front 31

Which group of isoenzymes areinvolved in the metabolism of more than 50% of all drug?

Back 31

Cytochrome P450