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6 Cards in this Set
- Front
- Back
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Why are PIs such a pain in the ass?
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-Highly protein bound, poor bioavailability
-Many drug interactions -Lots of dietary restrictions -Toxic bc of fxning proteases in human cells |
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What is the recommended regime in drug naive pts?
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NNRTI based
Efavirenz + (AZT/Tenofovir) + (3TC/Emtricitabine) PI based Kaletra + AZT + (3TC/Emtricitabine) Triple NRTI ABC + 3TC + AZT (only if first 2 cant be used) |
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What agents should NEVER be used in pregnant women?
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Efavirenz
ddC Delaviridine |
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When should pregnant women/infants start/stop using tx?
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C section benefits all women and kids
tx should start at 14 weeks. If earlier stop tx then begin again at 14 wks Baby should begin wi 6-12 hrs of birth |
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What do we do when there is Hep B or C co-infection?
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If you want to tx both HIV and HepB --->IFNa or b, 3TC
if only HepB tx is desired --->ADEFOVIR With Hep C, may hold until CD4 is >200, then IFN + Ribavarin |
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What are some of the major consequences of long term antiviral therapy?
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Lactic Acidosis
Diabetes Mellitus Fat redsitribution Hyperlipidemia |
