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10 Cards in this Set
- Front
- Back
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Cidal or static?
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Static
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Mechanism
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Binds 50S subunit
Binds at similar site as macrolides |
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Resistance
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Methylation of binding site
Cross-resistance with erythromycin |
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D-Test
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Erythromycin induces resistance in clindamycin
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Mechanism of cross-resistance
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Erythromycin binding causes expression of a methylase that methylates the 50S subunit
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Absorption
Distribution Metabolism Excretion |
Oral
Poor CSF Extensively metabolized to inactive Renal and bile |
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Pseudomembranous colitis treatment
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Stop antibiotic
Treat with metronidazole |
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Adverse effects
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Skeletal weakness
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Antimicrobial activity
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None activity on gram negative
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Clinical uses
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Gram +
Anaerobic |
