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8 Cards in this Set
- Front
- Back
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Step One |
Condensation of Acetyl CoA with Oxaloacetate to form Citrate. Enzyme: Citrate Synthase Water used, CoASH product |
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Step 2 |
Isomerization of citrate by Aconitase Citrate —> cis-aconitate—>isocitrate Enzyme: Aconitase Uses water, releases water |
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Step 3 |
Oxidative decarboxylation of isocitrate Enzyme: isocitrate dehydrogenase NAD+ used, NADH + H+ formed Alcohol to ketone Isocitrate—>alpha-ketoglutarate |
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Step 4 |
Oxidative decarboxylation of alpha-ketoglutarate Enzyme: alpha-ketoglutarate dehydrogenase CoASH to CO2 NAD+ to NADH Uses TPP, FAD, lipoate alpha-ketoglutarate—>succinly CoA |
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Step 5 |
Substrate level phosphorylation Enzyme: Succinyl CoA synthetase GDP+Pi --> GTP CoASH made succinyl CoA --> succinate |
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Step 6 |
Oxidation of Succinate to Fumarate Enzyme: succinate dehydrogenase FAD --> FADH2 succinate -- > fumarate |
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Step 7 |
Hydration of Fumarate to Malate Enzyme: Fumarase Water produced fumarate --> malate |
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Step 8 |
Oxidation of Malate to Oxaloacetate Enzyme: malate dehydrogenase NAD+ --> NADH malate --> oxaloacetate |
