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17 Cards in this Set

  • Front
  • Back

Chronic kidney Disease

Progressive, irreversible loss of kidney function and a decrease in the GFR.


Either a presence of kidney damage or a GFR of <60mL/min/1.73m for >3 months

Kidney Damage

Either pathological abnormalities, or markers, of damage, including abnormalities blood or urine tests or imaging studies

Causes of CKD

Diabetes mellitus, glomerulonephritis, hypertension, polycystic kidney disease

Stage 1-2

Polyuria (decreased ability to concentrate urine)


Nocturia

Stage 3

50% of nephron function lost


Hypertension


Elevated urea


Elevated Creatinine


Anaemia

Stage 3-4

Electrolyte imbalance


Abnormal bone and mineral metabolism

Stage 5

Life threatening


Odema


Worsening electrolyte imbalance


Metabolic acidosis


Multi system effects of uraemia

Risk factors - non modifiable

Age >50


Sex - male


Ethnicity


Family hx of kidney disease

Risk factors - modifiable

Smoking


Hypertension


Obesity


Diabetes

Signs and symptoms

Creatinine rise (after stage 3)


Hyperkalemia


Metabolic acidosis


Malnutrition - loss of lean body mass


Oedema - peripheral and pulmonary


Anaemia


Fatigue

Management - Primary

Screening, early detection (smoker? diabetes? hypertension? obesity? CV disease?)

Management - secondary

Prevent progression. Dietary changes, pharmacotherapeutics for managing hypertension, glycemic control, avoidance of nephrotoxins

Management - Tertiary

RRT, peritoneal dialysis, renal transplant, conservative treatment

KRT

Kidney Replacement Therapy

Glomerular Filtration Rate (GFR)

Is a test to see how well the kidneys are functioning. It estimates how much blood passes through the glomeruli each minute. Glomeruli are tiny filters in the kidneys that filter waste from the blood

Self management

Complex treatment regimes


Modify lifestyle (stop smoking, lose weight, limit alcohol intake and increase exercise)


Take numerous medications


Self-monitoring (BP, weight, BGLs)


Dialysis access (once necessary)

RRT

Renal Replacement Therapy