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9 Cards in this Set
- Front
- Back
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Granuloma |
localised aggregation of modified macrophages. focal area of granulomatous inflammation. |
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Epithelioid cells |
Activated macrophages. Finely granular, pale eosinophilic cytoplasm and central, ovoid nucleus, which is less dense than that of a lymphocyte. |
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Granulation Tissue |
Tissue of repair. |
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TB |
Basic pathology = granulomatous inflammation + caseous necrosis |
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Histology of granulomas |
T-lymphocytes and plasma cells on the periphery. Plasma cells have clock-face pattern of nuclear chromatin. |
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Histology of Epitheloid cells |
Eosinophilic cytoplasm, poorly defined cell borders and elongated nuclei. |
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Langhans cell |
Multi-nucleated giant cell, formed when materials digested by histiocytes cannot be degraded. Represent fusion of macrophages -- non-phagocytic. |
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Histology of Langhans cells |
Large cells, with peripheral nuclei. Nuclei form wither a u-shape or complete circle at the periphery of the cell. |
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Ghon Complex |
local spread in primary pulmonary TB infection subpleural granulomata, 1-2cm in size, at base of upper lobe or apex of lower lobe. |
