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16 Cards in this Set
- Front
- Back
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What is Cholinergic transmission? |
Transmission via ACh |
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ACh structure |
Acetate linked to choline through a ester linkage |
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What signals release of ACh from neurons? |
Voltage gated calcium channels open Signals release of ACh |
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Recycling of ACh/Choline |
ACh at synapse broken down into choline and aceate Choline reabsorbed into neuron terminal Acetate cleaved from AcetylCoa, free acetate bound to recycled choline Forming new ACh |
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What enzyme is responsible to breaking down ACH at synapse? |
Acetlycholineesterase, breaks the ester bond between choline and aceate, Forms choline and acetic acid |
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What enzyme transfers choline to acetate? |
Choline Acetyl Transferase |
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What are the 2 types of ACH receptor? |
1) Nicotinic Ligand-gated ion channel Fast transmission 2) Muscarinic GP-coupled Slow |
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ACh receptor diversity |
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Noradrenalin, and adrenalin structure What do they share? What is their difference? |
Both are catecholamines, they have a catechol group Adrenalin has a additional methyl group |
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What happens to Noradrenalin after release? |
Not broken down its reabsorbed Re-uptake helps to terminate the signal |
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Other than re-uptake by the neuron , how else is NE signal terminated? |
Intracellular metabolic enzymes 1) Monoamine oxidase (MAO) 2) Catechol-O-methyl transferase (COMT) |
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What is a ganglion? |
Collection of cell bodies outside CNS |
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Sympathetic NS organisation? |
Pre:- ACh, short Post:- Long, NE Thoracolumbar arrangement |
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Parasympathetic NS organisation? |
Pre:- ACh nicotinic, long
Post:- ACh muscarinic, long Craniosacral arrangement |
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Adrenal medulla |
Part of sympathetic Pre-ganglionic neuron synapses onto Adrenal medulla ACh nictonic Adrenal medulla releases NE and E into blood (hormones) |
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Vagus nerve? |
A parasympathetic nerve connected to the heart ACh acts of SA node, decreasing basal tone of heart Atropine is a drug that blocks the ACh receptor on SA node, increasing its heart rate |
