Chemotherapy Mcq

Front 1

60.1  Which of the following neoplastic diseases is almost curable by chemotherapy:

Back 1

Choriocarcinoma

Front 2

anticancer drug has high emetogenic potential:

Back 2

cisplatin

Front 3

Cancer Therapy true:

Back 3

Anticancer drugs increase the risk of develo- ping leukaemias and lymphomas several

years later

Front 4

Anticancer drugs weaken host defense by

Back 4

A. Damaging respiratory and gut epithelia
B. Inducing granulocytopenia

Front 5

Practically all antineoplastic drugs can produce the following toxic effects except:

Back 5

Cardiomyopathy

Front 6

Alkylating agents exert cytotoxic action by inducing:

Back 6

Breakage of DNA strand

Cross linking of DNA strands

Abnormal pairing of purine and pyrimidine

bases

All of the above

Front 7

Cyclophosphamide

Back 7

A. It is highly reactive and a vesicant on contact

Front 8

The most important target of action of chlorambucil is:

Back 8

Lymhoid tissue

Front 9

Methotrexate has the following attributes except:

Back 9

Folic acid reverses it's toxic

Front 10

The following antineoplastic drug is a mitotic inhibitor and causes metaphase arrest:

Back 10

vincristine

Front 11

Vinca alkaloids exert antitumor activity by:

Back 11

Inhibiting polymerization of tubulin to form

intracellular microtubules

Front 12

The following cytotoxic drug acts by inhibiting depoly- merization of tubulin and thus producing abnormal arrays of microtubules:

Back 12

Paclitaxel

Front 13

Vincristine differs from vinblastine in the following respect(s):

Back 13

A. Its prominent adverse effect is neuropathy B. It frequently produces alopecia
C. It does not significantly depress bone marrow D. All of the above

Front 14

What is true of docetaxel:

Back 14

It is used as a reserve drug for refractory

breast and ovarian cancer

Front 15

Topotecan

Back 15

It is a DNA topoisomerase I inhibitor which

causes single strand DNA breaks

It is a cell cycle specific anticancer drug

Front 16

The characteristic toxicity of doxorubicin is:

Back 16

Cardiomyopathy

Front 17

Thioguanine differs from mercaptopurine in that:

Back 17

It is not metabolized by xanthine oxidase

It does not cause hyperuricemia

Front 18

Patients treated with the following anticancer drug are likely to develop a disulfiram like reaction on taking alcohol:

Back 18

B. Procarbazine

Front 19

The following is true about use of prednisolone in malignant diseases except:

Back 19

It is curative in acute childhood leukaemia

Front 20

The following does not apply to cancer chemo- therapy:

Back 20

Each treatment with a cytotoxic drug kills a constant number of malignant cells

Front 21

Select the cell cycle nonspecific antineoplastic drug:

Back 21

D. 5-Fluorouracil

Front 22

Mesna is administered with cyclophosphamide and ifosphamide to:

Back 22

D. Ameliorate cystitis caused by them

Front 23

Biological response modifiers like GM-CSF are used in conjunction with anticancer drugs for the following purpose(s):

Back 23

To hasten recovery from drug induced myelo-

suppression

Front 24

Thalidomide

Back 24

It ameliorates cancer associated cachexia

Front 25

Select the drug which is used exclusively in organ transplantation and autoimmune diseases, but not in cancers:

Back 25

Cyclosporin

Front 26

Cyclosporine has the following attributes except:

Back 26

It selectively suppresses humoral immunity

without affecting cell mediated immunity