Chemo Naplex

Front 1

MTX toxicities

Back 1

myelosuppression, mucositis, nephrotoxicity

Front 2

MTX targets

Back 2

DNA synthesis- antimetabolite

Front 3

What drug requires leucovorin rescue in high doses?

Back 3

MTX

Front 4

how can you prevent nephrotoxicity with MTX?

Back 4

Sodium Bicarb in IV

Front 5

Pemetrexed Alimta has two major AE what are they how do you treat/prevent

Back 5

Cutaneous reaction- dexamethasone day before, that day, day after

Hematologic
folic acid
B12

Front 6

Cladribine
brand
class

Back 6

Leustatin
Purine Analog

Front 7

Which drug do you have to reduce by 75% when given with ZYloprim?

Back 7

6-mercaptopurine- Purinethol

Front 8

Cytarabine
Brand
Class

Back 8

Cytosar
Pyrimidine analog

Front 9

What do you give a patient with Plantar-Palmar syndrome from Cytosar?

Back 9

hydrocortisone

Front 10

5-FU
Bolus toxicity
Continuous toxicity

Back 10

bolus- myelosuppression
Continuous- mucositis, bloody diarrhea

both can cause Plantar-palmar

Front 11

Capecitabine (Xeloda) is the oral form of __________-

Back 11

5-FU

Front 12

Camptosar

Back 12

irinotecan

Front 13

topotecan

Back 13

Hycamtin

Front 14

Do not give doses of oncovin (vincristine) in doses greater than 2gm/m2 due to _________

Back 14

irreversible neurotoxicity

Front 15

Cisplatin
brand MOA

Back 15

platinol

Front 16

Carboplatin
Brand & MOA

Back 16

paraplatin
alkylating

Front 17

Oxaliplatin

Back 17

Eloxatin
alkylating

Front 18

chlorambucil

Back 18

Leukeran
alkylating

Front 19

Procarbazine

Back 19

Matulane
Alkylating

Front 20

Busulfan

Back 20

Myleran
alkylating

Front 21

Dacarbazine

Back 21

DTIC
alkylating

Front 22

Ifosfamide

Back 22

mitoxana
alkylating

Front 23

Cyclophosphamide

Back 23

Cytoxan
alkylating

Front 24

Ifosfamide and Cylophosphamide can both cause __________

Back 24

hemorrhagic cystitis

Front 25

SIADH can be caused by

Back 25

cytoxan

Front 26

Mercaptoethane Sodium is used for _________--

Back 26

pretreatment with ifosfamide to prevent hem cystitis

Front 27

Carboplatin major toxicity

Back 27

myelosuppresion

Front 28

Cisplatin 2 major SE

Back 28

nephrotoxicity & Vomiting (very emetic)

Front 29

How is carboplatin dosed?

Back 29

AUC

Front 30

Patient is receiving cisplatin. What can you give them to prevent damage to normal tissue?

Back 30

Amifostine (Ethyol)
hypotension big

Front 31

Which chemo drug causes problems when drinking cold liquids due to peripheral neuropathies?

Back 31

Eloxatin (oxaliplatin)

Front 32

Name 4 oral alklyating agents

Back 32

Chlorambucil (Leukeran)
Busulfan (Myleran)
Melphalan (Alkeran)
Temazolamide (Temadar)

Front 33

Carmustine and lomustine are a part of the ______ class which work as alkylating agents

Back 33

nitrosureas

Front 34

What is the MOA of the anthracene derivatives?

Back 34

Inhibition of topoisomerase II- form free radicals
Doxorubicin, daunorubicin,Idarubicin

Front 35

What are the 6 major SE of the anthracenes?

Back 35

1. myelosuppression
2. cardiotoxicity
3. Extravasation
4. NV
5. Mucositis
6. red/orange urine discoloration

Front 36

Acutely doxorubicin can cause __________ chronically _________

Back 36

arrhythmias, cardiomyopathy

Front 37

Dexrazoxane
Brand
Use

Back 37

Zinecard
prevent free radical formation given in 10:1 ratio to doxo.
approved in women with metastatic breast cancer who have received 300mg/m2 and still getting benefit

Front 38

Doxorubicin

Back 38

Adriamycin
topoisomerase II

Front 39

Daunorubicin

Back 39

Cerubidine
TopoIsomerase II

Front 40

Mitoxantrone

Back 40

Novantrone
anthracenedione not an anthracycline

Front 41

Counseling tip for Novantrone?

Back 41

blue-green urine discoloration

Front 42

Bleomycin
Brand
Class
SE

Back 42

Blenoxane
Anthracycline
B for breathing toxicity

Front 43

Mitomycin C
Brand
Class
How is it used in bladder cancer

Back 43

Mutamycin
Anthracycline
Intravesicularly- shake and Bake

Front 44

WHen would you begin leucovorin rescue for MTX?

Back 44

24 hrs post dose

Front 45

Cytarabine
brand
class

Back 45

Cytosar
Pyrimidine antagonist

Front 46

Gemcitabine

Back 46

Gemzar
pyrimidine antagonist

Front 47

Capcitabine

Back 47

Xeloda
pyrimidine antagonist

Front 48

Floxuradine

Back 48

FUDR
pyrimidine antagonist

Front 49

5-FU

Back 49

fluorouracil
pyrimidine antagonist

Front 50

moa OF pyrimidine antagonists?

Back 50

inhibits DNA polymerase causing premature chain termination

Front 51

Name two toxicities associated with high dose Ara-C?

Back 51

cytarabine
1. CNS - cant write name anymore
2. chemical conjuctivitis- steroid eyedrops

Front 52

What is the difference between gemzar and cytosar?

Back 52

gemzar- intermittent dosing qw q3w

gemzar more effective for solid tumors
dont get CNS toxicity

Front 53

Clofarabine

Back 53

Clolar
pyrimidine antagonist

Front 54

Nelarabine

Back 54

Arranon
pyrimidine antagonist

Front 55

What is the MOA of 5-FU

Back 55

metabolized to FdUMP which binds to thymidylate synthase preventing conversion from uracil to thymidine
RNA to DNA

Stabilizes TS and FdUMP in the presence of leucovorin

Front 56

Vinca alkaloids MOA

Back 56

inhibit mitosis by binding to tubules inhibiting microtubule assembly

Front 57

Vincristine

Back 57

Oncovin
vinca alkaloid

Front 58

Vinblastine

Back 58

Velban
vinca alkaloid

Front 59

Vinorelbine

Back 59

Navelbine
vinca

Front 60

Paclitaxel

Back 60

Taxol
Taxoid

Front 61

Docetaxel

Back 61

Taxotere

Front 62

What is the max dose of Oncovin?

Back 62

2mg

Front 63

Max dose of Velban?

Back 63

8mg/m2

Front 64

Major SE of vinblastine?

Back 64

B for bone marrow --> myelosuppresion
also vessicant, extravasation

Front 65

Vincristine major SE's

Back 65

Neurotoxicity, vesicant, extravasation, SIADH, constipation

Front 66

What is the MOA of the taxoids?

Back 66

induce polymerization of tubulin resulting in non-functioning microtubules that inhibit mitosis

Front 67

Premedicated
Taxol w/
Taxotere w/
FOR

Back 67

steroids, histamine antagonist
hypersensitivity reactions

dexamethasone- fluid retention

Front 68

Taxoid class SE's

Back 68

peripheral neuropathy
neutropenia
mucositis
alopecia
hypersensitivity reactions

Front 69

Epipodophyllotoxins

Back 69

etoposide
teniposide

Topoisomerase II inhibitors

Front 70

Camptothecins

Back 70

irinotecan (Camptosar)
Hycamtin- Topotecan

topoisomerase I inhibitors

Front 71

How do you treat ab cramping with irinotecan?

Diarrhea?

Back 71

atropine

lomotil, immodium

Front 72

L-asparaginase
3 toxicities and what to do

Back 72

pancreatitis- check amylase

decreased fibrinogen- give cryoprecipitate

Hypersensitivity- give Erwina or PEG asparaginase

Front 73

how is Velcade dosed?

Back 73

Bortezomib is biweekly

Front 74

What is the MOA of Bortezomib?

Back 74

proteasome inhibitor

Front 75

What is ATRA (Vesinoid) given with ?

Back 75

Cytosar and daunorubicin

Front 76

Azacitadine

Back 76

Vidaza

Front 77

Decitabine

Back 77

Dacogen

Front 78

Rituximab

Back 78

Rituxan
Anti-CD20
B-cell non-hodgskins lymphoma

Front 79

Gemtuzumab

Back 79

Mylotarg

Front 80

Alemtuzumab

Back 80

Campath
Anti-CD52

Front 81

Zevalin

Back 81

ibritumomab- given w/ rituxan

Front 82

Tositumomab

Back 82

Bexxar

Front 83

Vectibix
generic name
indication

Back 83

Panitumumab
EFGR expressed metastatic colorectal carcinoma

Front 84

Bevacizumab
Brand
indication

Back 84

Avastin
colorectal

Front 85

Cetuximab
brand
indication

Back 85

Erbitux
metastatic colorectal cancer

Front 86

Her-2 positive breast cancer

Back 86

Trastuzumab (Herceptin)

Front 87

Herceptin can cause ___________

Back 87

CHF

Front 88

Gefitinib

Back 88

Iressa
NSCLC

Front 89

Erlotinib

Back 89

NSCLC
Tarceva

Front 90

Imatinib MOA

Back 90

Gleevec
Bcr-Abl tyrosine kinase inhibitor for Philly Chromosome + CML

Front 91

Mechloretamine

Back 91

Mustargen

Front 92

Altretamine

Back 92

Hexalen

Front 93

Thiotepa

Back 93

thioplex
alkylating

Front 94

Streptozocin

Back 94

Zanosar
alkyl

Front 95

Pentostatin

Back 95

Nipent
Purine

Front 96

Tamoxifen

Back 96

Nolvadex

Front 97

Fulvestrant

Back 97

Faslodex

Front 98

Toremifene

Back 98

Fareston
anti-estrogen

Front 99

Exemestane

Back 99

Aromasin

Front 100

Anastrazole

Back 100

Arimidex

Front 101

Letrozole

Back 101

Femara

Front 102

Abraxane

Back 102

paclitaxel

Front 103

Denileukin diftitox

Back 103

Ontak

Front 104

Ibritumomab

Back 104

Zevalin
NHL

Front 105

Erlotinib

Back 105

Tarceva

Front 106

Sutinib

Back 106

Sutent

Front 107

Dasatinib

Back 107

Sprycel