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13 Cards in this Set
- Front
- Back
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Histamine |
- Preformed mediator in secretory granule - mast cells, basophils and platelets - vasodilation, increased capillary permeability to form exudate |
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Chemotactic factors |
- mast cell granules - attract neutrophils to the site |
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Kinins |
- activation of plasma protein (kinogen) - vasodilation, increased capillary permeability, pain and chemotaxis |
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Serotonin |
- preformed in secretory granules - platelets |
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Lysosomal enzymes |
- preformed in secretory granules - neutrophils and macrophages |
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Prostaglandins |
- newly synthesized from arachidonic acid in mast cells - all leukocytes, platelets and EC - vasodilation, increased capillary permeability, pain, fever, potential histamine effects |
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Leukotrines |
- newly synthesized from arachidonic acid in mast cells - all leukocytes - late response: vasodilation and increased capillary permeability and chemotaxis - |
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Platelet activating factors |
- newly synthesized - all leukocytes and EC, cell membrane of platelets - activates neutrophils and platelet aggregation |
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Activated oxygen species |
- all leukocytes |
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Nitric oxide |
- macrophages |
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Cytokines |
- newly synthesized - interleukins, lymphokines: T lymphocytes, macrophages and EC - increased plans proteins, ESR, induce fever, chemotaxis and leukocytosis |
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Factor XII activation l |
- from the liver - kinin system/bradykinin and coagulation/fibrinolysis system |
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Complement activation |
- from the liver - activation of plasma protein cascade - vasodilation, increased capillary permeability, chemotaxis and increased histamine release |
