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33 Cards in this Set

  • Front
  • Back

Characteristics of Muscle

Excitablility(Responsivness): Nerve


Conductivity:


Contractility: Can contract


Extensibility: Stretches


Elasticity: Recoils



Skeletal Muscle

Voluntary, Striated muscle attached to bones.



Myofiber

Muscle fibers

Epimysium

aka Fascia



perimtsium

Around each fascicles

Endo museum

Between each muscle fiber

Synapse

Where two cells meet

Neuromuscluar Junctions

Where a nerve fiber makes a s functional connection with its target muscle cell

Components of Synapse

*Synnaptic knob (contains acetylcholine)


*

Electrically excitable cells

Plasma membrane is polarized/charged (resting membrane potential)


Due to imbalance of charged ions.



Muscle stages of contraction and relaxation

1. Excitation


2. Excitation-Contration


3. Contraction


4. Relaxation



Excitation

1. Action Potentional (AP) arrive at neuromuscular lunch ion (NMJ)


2. AP opens voltage-gated calcium channels on synaptic knob.


3. Calcium enter synaptic knob and triggers exocytosis of synaptic vesicles containing ACh(Acetylcholine).


4. ACh enters synaptic cleft


5. ACh binds to ACh receptors on motor end-plate( part of sacrolemma)


6. Opens ligand-gated Na channels.


7. Na influx followed quickly by K efflux


8. AP spreads across sacrolemma

Depolarization

When you go from negative to positive in cell

Repolarization

When you go from positive to negative in cell.

Excitation-Contraction Coupling

1. AP propagates (spreads) down the T-Tubules


2. AP triggers release of calcium from terminal cistermea of SR (Sacroplasmic reticulum)



Contraction

Power stroke, shows myosin e=heads releasing ADP and phosphate

Relaxation

Cessation of nervous stimulation and ACh release, ACh Breaks down by AChe

Rigor Mortis

Stiffening of body after death due to loss of ATP

Muscle Metabolism

ATP is generated by



Anaerobic Pathway

2 ATP for each glucose

Muscle fatigue

Inability to contract.



Oxygen Deficit

Extra O2 needed for O2 reserve Glycogen stores, and ATP and CP reserves

Heat production during muscle activity

60%....

Three types of Mucle cells

Slow oxidative fibers (Red): Endurance, Slow




Fast Oxidative Fibers(Red/Pink): Sprinting/Walking




Fast glycolytic: (Pale) Quick actions.

Principles of Mucle Mechanics

Contraction may/may not shorten muscle




Isometric contraction: No shortening; Mucle tension increases but does not exceed load




Isotonic: mucles shortening because Mucle tension exceeds load.



Motor unit

Motor neuron and all muscle fibers it supplies.

Three phase of Mucle twitch

Latent: Period excitation and contraction


Contraction:


Relaxation:

Temporal (wave) summation

Increased stimulus frequency( muscle does not completely relax between stimuli) >>> Second contraction of great force





Tenany

Maximal tension reached

Recruitment

Controls force of contraction (multiple motor unit summation)

Isotonic Contractions

Muscle changes in length and moves load




Concentric contractions: muscle shorten and does work



Eccentric contractions: Muscle lengthens whilst maintaining tension.



Isometric

Muscle does not " " in length

Muscle tone

Optimum resting length (actin and myosin, still overlap, to prepare to be used)