Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
16 Cards in this Set
- Front
- Back
|
What characteristics do the herpes viruses have in common?
|
1. Can develop a latent state - sensory ganglia
2. Sub-family alpha members have a cytopathic effect on cells, which become multinucleated giant syncytial cells with intranuclear inclusion bodies 3. Herpes viruses are held at bay by cell mediated immunity |
|
|
What are the alpha sub group herpes viruses?
|
HSV1 and HSV2, varicella-zoster
|
|
|
Which herpes viruses have less cytopathic effects than the alpha sub group viruses?
|
CMV and EBV
|
|
|
Clinical symptoms, when present, of HSV1 infections are...?
|
1. gingivostomatitis
2. reactivation - during stressed states, AIDS patients 3. Herpetic keratitis - corneal blindness 4. Encephalitis |
|
|
What is the most common cause of viral encephalitis in the US?
|
HSV 1
|
|
|
HSV2 often causes which types of disease, in contrast to HSV1?
|
Genital disease that is sexually transmitted
|
|
|
What organisms can cross the blood-placenta barrier?
|
Think TORCHES:
TO - TOxoplasmosis R - Rubella C - Cytomegalovirus HE - HErpes, HIV S - Syphilis |
|
|
VZV causes which diseases?
|
Varicella and herpes zoster
|
|
|
What is the course and clinical manifestations of varicella infection?
|
Fever, malaise, and headache, followed by characteristic rash - red base with fluid-filled vesicles.
|
|
|
Describe the localization of zoster infection?
|
During reactivation, the latent VZV replicates and migrates to the peripheral nerves, causing burning and painful skin lesions in a dermatotomal distribution.
|
|
|
What is the most common viral cause of mental retardation?
|
CMV
|
|
|
What are the infectious states caused by CMV?
|
1. Asymptomatic infection
2. Congenital disease 3. CMV mononucleosis 4. Reactivation in the immunocompromised patient |
|
|
Distinguish the CMV diseases in AIDS patients versus bone marrow transplant patients?
|
AIDS patients - CMV viremia, CMV retinitis, and CMV colitis
Transplant patients - CMV pneumonitis |
|
|
EBV causes?
|
Mononucleosis and Burkitt's lymphoma
|
|
|
Describe EBV infection?
|
EBV infects human B-cells, which transform and proliferate. The immune system eventually destroys the infecting virus as well as the abnormal B cells.
|
|
|
Describe the clinical manifestations of "mono"?
|
Fever, chills, sweats, headaches, and a very painful pharyngitis. Enlarged lymph nodes and sometimes an enlarged spleen.
|
