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46 Cards in this Set

  • Front
  • Back
The replisome consists of all of the following proteins except _________.
two copies of the pol III holoenzyme
the primosome
DNA unwinding proteins
The experiment that demonstrated the mechanism whereby DNA is synthesized was performed by ___
Matthew Meselson
Franklin Stahl
The _____ are enzymes that catalyze the unwinding of duplex DNA.
helicases
SSB are
single-stranded DNA-binding protein that keep single strands of DNA apart during replication
The background rate of spontaneous mutations is approximately ________ mutations per gene per million gametes
1 mutation per 100,000 genes per generation ????
DNA polymerase β is believed to be involved in
Sliding clamp
Nuclear DNA repair
Mutations are caused by all of the following except ________.
...
DNA molecules are copied or replicated by a _______ mechanism.
semiconservative
The tangling of DNA strands during replication is prevented by _________.
topoisomerases
The rate of DNA synthesis in eukaryotes is approximately_________ nucleotides per ________ per replication fork.
50 nucleotides per second per replication fork
In the eukaryotic cell cycle the M(itosis) phase occurs after the ______ phase.
G2
_______ is a form of intermicrobial DNA transfer that occurs when bacteriophage inadvertantly serve as carriers of bacterial DNA to the recipient cell.
Transduction
The initiation of transcription involves the binding of RNA polymerase to a specific sequence called a __________.
promoter
All of the following gene products are coded for by constitutive genes except ______.
...
The reassortment of DNA sequences is called
recombination
_______ are tumors that arise in connective tissue.
sarcomas
______ is a protooncogene that codes for a GTP-binding protein.
RAS
______ is a protooncogene that codes for platelet-derived growth factor.
SIS
_______ is a product of a delayed response gene.
CDK
Cyclin
other components required for cell division
______ is an enzyme that catalyzes a critical step in replicative transposition.
Resolvase
DNA synthesis is called
replication
_______ catalyzes the transcription of the precursor of the tRNAs and 5S rRNA.
...
DNA transposition can cause gene ______.
...
Many promoters for RNA polymerase II contain a consensus sequence call the _______.
TATA box
Place the following steps of general recombination in chronological order
i. DNA ligase seals the cut ends
ii A second series of DNA strand cuts occurs opposite the first crossover strands
iii Two homologus DNA molecules become paired
iv DNA polymerase fills any gaps and DNA ligase seals the cut strands
v Two of the DNA strands are cleaved
vi The two strand segments cross over
III, V, VI, I, II, IV (669)
Most of the carcinogenic effects of radiation are believed to be the result of _______.
formation of ROS caused by radiation exposure
DNA is synthesized in which of the following directions
5'-3'
All of the following play a role in DNA repair except ________.
...
In the absence of its inducer the lac operon remains repressed because of the binding of lac repressor to the _______.
...
Eukaryotic gene expression is affected by all of the following except ______.
...
The majority of genetic variations arise from
...
Topoisomerases
prevent tangling of DNA strands
Type II topoisomerases
produce transient double strand breaks
In higher eukaryotes replication begins with the
sequential assembly of the preinitiation replication complex (preRC)
Light-induced repair will correct which of the following mutations
pyrimidine dimers
In nucleotide excision repair
bulky, helix-destabilizing lesions are removed, and the resulting gap is filled
Insertion of viral DNA into a host cell's genome is an example of
site specific recombination
Genomic libraries are produced by
shotgun cloning
Homology modeling facilitates
prediction of protein structures
Protooncogenes are
normal genes that if mutated can promote carcinogenesis
An exonuclease is an enzyme that
removes nucleotides from the end of the polynucleotide strand
Repair of DNA by the SOS system has a major disadvantage
...
A difference between prokaryotic and eukaryotic DNA polymerases is:
...
The average natural mutation rate for plants and animals is one mutation per ______ genes/generation.
100,000
____________ repair occurs only on a strand actively being transcribed,
Transcription coupled repairs
__________ corrects replication proofreading errors.
Mismatch repair