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46 Cards in this Set
- Front
- Back
The replisome consists of all of the following proteins except _________.
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two copies of the pol III holoenzyme
the primosome DNA unwinding proteins |
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The experiment that demonstrated the mechanism whereby DNA is synthesized was performed by ___
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Matthew Meselson
Franklin Stahl |
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The _____ are enzymes that catalyze the unwinding of duplex DNA.
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helicases
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SSB are
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single-stranded DNA-binding protein that keep single strands of DNA apart during replication
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The background rate of spontaneous mutations is approximately ________ mutations per gene per million gametes
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1 mutation per 100,000 genes per generation ????
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DNA polymerase β is believed to be involved in
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Sliding clamp
Nuclear DNA repair |
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Mutations are caused by all of the following except ________.
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...
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DNA molecules are copied or replicated by a _______ mechanism.
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semiconservative
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The tangling of DNA strands during replication is prevented by _________.
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topoisomerases
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The rate of DNA synthesis in eukaryotes is approximately_________ nucleotides per ________ per replication fork.
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50 nucleotides per second per replication fork
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In the eukaryotic cell cycle the M(itosis) phase occurs after the ______ phase.
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G2
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_______ is a form of intermicrobial DNA transfer that occurs when bacteriophage inadvertantly serve as carriers of bacterial DNA to the recipient cell.
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Transduction
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The initiation of transcription involves the binding of RNA polymerase to a specific sequence called a __________.
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promoter
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All of the following gene products are coded for by constitutive genes except ______.
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...
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The reassortment of DNA sequences is called
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recombination
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_______ are tumors that arise in connective tissue.
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sarcomas
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______ is a protooncogene that codes for a GTP-binding protein.
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RAS
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______ is a protooncogene that codes for platelet-derived growth factor.
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SIS
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_______ is a product of a delayed response gene.
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CDK
Cyclin other components required for cell division |
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______ is an enzyme that catalyzes a critical step in replicative transposition.
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Resolvase
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DNA synthesis is called
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replication
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_______ catalyzes the transcription of the precursor of the tRNAs and 5S rRNA.
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...
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DNA transposition can cause gene ______.
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...
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Many promoters for RNA polymerase II contain a consensus sequence call the _______.
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TATA box
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Place the following steps of general recombination in chronological order
i. DNA ligase seals the cut ends ii A second series of DNA strand cuts occurs opposite the first crossover strands iii Two homologus DNA molecules become paired iv DNA polymerase fills any gaps and DNA ligase seals the cut strands v Two of the DNA strands are cleaved vi The two strand segments cross over |
III, V, VI, I, II, IV (669)
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Most of the carcinogenic effects of radiation are believed to be the result of _______.
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formation of ROS caused by radiation exposure
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DNA is synthesized in which of the following directions
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5'-3'
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All of the following play a role in DNA repair except ________.
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...
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In the absence of its inducer the lac operon remains repressed because of the binding of lac repressor to the _______.
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...
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Eukaryotic gene expression is affected by all of the following except ______.
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...
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The majority of genetic variations arise from
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...
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Topoisomerases
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prevent tangling of DNA strands
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Type II topoisomerases
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produce transient double strand breaks
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In higher eukaryotes replication begins with the
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sequential assembly of the preinitiation replication complex (preRC)
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Light-induced repair will correct which of the following mutations
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pyrimidine dimers
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In nucleotide excision repair
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bulky, helix-destabilizing lesions are removed, and the resulting gap is filled
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Insertion of viral DNA into a host cell's genome is an example of
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site specific recombination
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Genomic libraries are produced by
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shotgun cloning
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Homology modeling facilitates
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prediction of protein structures
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Protooncogenes are
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normal genes that if mutated can promote carcinogenesis
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An exonuclease is an enzyme that
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removes nucleotides from the end of the polynucleotide strand
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Repair of DNA by the SOS system has a major disadvantage
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...
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A difference between prokaryotic and eukaryotic DNA polymerases is:
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...
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The average natural mutation rate for plants and animals is one mutation per ______ genes/generation.
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100,000
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____________ repair occurs only on a strand actively being transcribed,
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Transcription coupled repairs
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__________ corrects replication proofreading errors.
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Mismatch repair
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