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11 Cards in this Set

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Inactive proteins until cleaved by proteases


C3b and C4b


Inflammatory mediators. Enhances blood flow to area. C3a and C5a

Membrane Attack Complex (MAC)

Proteins of MAC insert into cell membranes of antigens and punch holes.

C3 convertases

Cleaves C3 into C3a and C3b. C4b2a in classical and lectin pathway. C3bBb in alternative pathway.

C5 convertases

Formed by addition of C3b to a C3 convertase. Cleaves C5 into C5a and C5b. C5a is an anaphylatoxin, c5b is MAC initiator

Classical Pathway of Complement Activation

Adaptive immune response. Begins with antigen antibody complex. Only complexes formed with IgM or IgG able to activate. C1q--> C1r, C1s, C1s cleaves C4, C4b binds membrane, C4b binds C2, C1s cleaves C2, C4b2a is created (C3 convertase), C3 convertase lyses C3, C3 convertase binds C3b for C5 convertase.

Lectin Pathway of Complement Activation

Instead of using antibodies to recognize threat, uses lectins.

Alternative Pathway of Complement Activation

Tickover- C3 constantly made. C3 with h2o cleaves Factor B, then Factor D

Properdin- initiates and stabilizes alternative pathway. Properdin with C3b and Factor B cleaves Factor D

Protease- thrombin cleaves c5


Proteins that recognize particular carb components


C3 convertase unstable until bound to properdin, a serum protein.