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11 Cards in this Set
- Front
- Back
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Zymogens |
Inactive proteins until cleaved by proteases |
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Opsonins |
C3b and C4b |
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Anaphylatoxins |
Inflammatory mediators. Enhances blood flow to area. C3a and C5a |
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Membrane Attack Complex (MAC) |
Proteins of MAC insert into cell membranes of antigens and punch holes. |
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C3 convertases |
Cleaves C3 into C3a and C3b. C4b2a in classical and lectin pathway. C3bBb in alternative pathway. |
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C5 convertases |
Formed by addition of C3b to a C3 convertase. Cleaves C5 into C5a and C5b. C5a is an anaphylatoxin, c5b is MAC initiator |
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Classical Pathway of Complement Activation |
Adaptive immune response. Begins with antigen antibody complex. Only complexes formed with IgM or IgG able to activate. C1q--> C1r, C1s, C1s cleaves C4, C4b binds membrane, C4b binds C2, C1s cleaves C2, C4b2a is created (C3 convertase), C3 convertase lyses C3, C3 convertase binds C3b for C5 convertase. |
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Lectin Pathway of Complement Activation |
Instead of using antibodies to recognize threat, uses lectins. |
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Alternative Pathway of Complement Activation |
Tickover- C3 constantly made. C3 with h2o cleaves Factor B, then Factor D Properdin- initiates and stabilizes alternative pathway. Properdin with C3b and Factor B cleaves Factor D Protease- thrombin cleaves c5 |
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Lectin |
Proteins that recognize particular carb components |
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Properdin |
C3 convertase unstable until bound to properdin, a serum protein. |
