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16 Cards in this Set
- Front
- Back
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available bisphosphonates
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alendronate, etidronate, risedronate, pamidronate, tiludronate, zoledronic acid
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MOA of bisphosphonates
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inhibits osteoclast bone resorption
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uses of bisphosphonates
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osteoporosis, Paget's disease, osteolytic bone lesions, and hypercalcemia frrom malignancy
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major SE of bisphosphonates
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chemical esophagitis
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bisphosphonates that cannot be used on continuous basis because it caused osteomalacia
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etidronate
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used for prevention of postmenopausal osteoporosis in women
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estrogen (HRT- hormone replacement therapy)
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increase bone density, also being tested for breast CA tx
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raloxifene (SERM)
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used especially in postmenopausal women, dosage should be 1500 mg
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calcium
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vitamin to be coadministered with calcium to ensure proper absorption
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vitamin D
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cinacalcet
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lower PTH by activatin Ca-sensing receptor in parathyroid gland- oral Tx of secondary hyperparathyroidism in chronic kidney disease and hypercalcemia in those with parathyroid carcinoma
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bisphosphonates with daily oral dosing
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alendronate, risedronate, ibandronate
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bisphosphonates with weekly oral dosing
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alendronat, risedronate
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bisphosphonate with monthly oral dosing
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ibandronate
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bisphosphonate with quarterly injection
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ibandronate
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bisphosphonate with annual infusion
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zoledronate
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higher doses of bisphosphonates used to treat hypercalcemia have been associated with
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renal impairment and osteonecrosis of the jaw
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