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9 Cards in this Set
- Front
- Back
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what is inflammation?
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a normal protective response to tissue injury caused by physical trauma, noxious chemicals or microbiological agents
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what is the function of Leukotrienes?
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Vascular permability
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what is the function of prostaglandiins?
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hyperalgesia
vasodilaiton vascular permeability all leading to inflammation |
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Describe what a prostaglandin is and what it does?
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unsaturated fatty acid derivatives with 20 carbon atoms (eicosandoids)
produced in minute quantities by all tissues act locally on tissues where they are produced rapid metabolized to inactive products at their site of action do not circulate in the blood in significant quantities |
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what type of therapy are NSAIDS used for?
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inflammation
pain fever |
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how do NSAIDS work on treating inflammation?
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Erythema, edema, hyperalgesia
- prostaglandins and other cell mediators -autoimmunity (rheumatoid arthritis) - infectious agents, ischemia, physical injury |
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what is the therapeutic indication NSAIDS in pain?
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sensitization of pain fivers by prostaglandins
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what is the therapeutic indication of NSAIDS for fever?
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pyrogenic stimulus release cytokiens, increases PG in hypothalamus, increases temperature, and decreased heat loss
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Do NSAIDS inhibit lipoxygenase and cyclooxygenase?
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NO
NSAIDS only inhibit cyclooxygenase but NOT lipoxygenase |
