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64 Cards in this Set
- Front
- Back
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Site of ag independent lymphopoiesis producing B cells, T cells precursors |
Bone marrow |
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Site of T cell maturation |
Thymus |
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Major antigen-trapping sites of the body |
Lymph nodes |
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Consists of red & white pulp Largest secondary lymphoid organ |
Spleen |
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Site of maturation of T cell |
Thymus |
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Site of maturation of B cell |
Bone marrow |
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Alpha beta chains. Only recognizes processed ag |
TCR |
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SIgM and SIgD. Recognized raw antigens |
BCR |
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sRBC receptor in a rosette assay |
CD2 |
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Present in all t cells. Tcr-assoc signal transduction molecule. Pan marker of T cell |
CD3 |
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Expressed by Th cell, interacts w/ MHC Class II |
CD4 |
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Expressed by Tc cell, interacts w/ MHC Class I |
CD8 |
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Binds ot CD40 on B cells |
CD40 Ligand |
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B cell coreceptor, signal transduction, pan marker of b cells |
CD19 |
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Calcium channel |
CD20 |
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Receptor for complement C3d & EBV |
CD21 |
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Required for class switch signals from T cells (isotype switching) |
CD40 |
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Antigen presentation of B cells |
MHC class I |
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Recognized lipoprotein in mycobacteria |
TLR1 |
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Binds to peptidoglycan in gram pos bacteria |
TLR2 |
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DsRNA of viruses |
TLR3 |
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Recognizes lipopolysaccharide in gram neg bacteria |
TLR4 |
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Flagiline |
TLR5 |
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Opsonization and immune clearance, largest conc. in serum, convergence point |
C3 |
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Activation of lectin pathway |
MBP |
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Exerts bacterial and viricidal effects in the presence of C3 and Mg, stabilizes C3 convertase |
Properdin |
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Heat stable cationic substances with antibacterial activity |
Betalysin |
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Mediate rolling of neutrophil |
Selectins |
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Facilitate firm transient adhesion prior to transmigration |
Integrins |
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Squeezinh btw junctions in the endothelial wall of bv |
Diapedesis |
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Migration of leukocytes primarily neutrophils to the site of injury |
Chemotaxis |
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Coating of microbial particles to facilitate phagocytosis |
Opsonization |
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Group of >30 proteins involved in phagocytosis and clearance of foreign antigens |
Complement |
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Suppress immune response to self; CD4+ CD25 + |
T regulator cell |
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Inhibit T helper cells |
T supressor cell |
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CD8 pos, recog ag in assoc w/ mhc class i, destroy target cells through release of perforins, granzymes, and cytokines |
T cytotoxic cell |
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Stimulate b cell division and differentiation; secrete Il-4,5,6,10,13, factors IgE rxn |
Th2 cells |
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Initiate delayed type hypersensitivity rxns and help in the dev of cd8 tc cells; secretes IL-2, IFN-Y, TNF; important in immunity to intracellular pathogens |
Th1 cells |
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Diff into Th1 or Th2 cells |
Th0 cells |
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CD4 pos; 55-70% of peripheral t cells; collab with b cells to induce humoral immune response; recognize ag in assoc with mhc class II |
T helper cell |
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Panmarker (expressed until maturity); regulates B cell development |
CD19 |
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Ion channel |
CD20 |
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Receptor for C3d & EBV |
CD21 |
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Heat stable antigen/ cell adhesion molecule |
CD24 |
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IL2 receptor alpha chain |
CD25 |
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Signaling molecules |
CD45r |
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Memory cell |
CD40 |
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Leukocyte (3) |
CD, CD-45, CD-47 |
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T lymphocyte (3) |
CD 2,4,8 |
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Pre-B lympo, common ALL (CALA+, ALL(L1) |
CD10 |
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Monocytes, granulocytes, platelets |
CD12 |
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Granulocytes |
CD15 |
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B lympocytes (3) |
CD - 19, 24, 39 |
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T lymphocytes, plasma cell |
Cd27 |
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Myeloid leukemia |
CD33 |
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Hematopoietic stem cells |
CD 34 |
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B, lymphocyte, macrophage |
CD 39 |
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Glycoprotein IIb/IIIa |
CD 41a |
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Macrophage |
CD68 |
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Activated lymphocyte |
CD69 |
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Reed sternberg cells |
CDw70 |
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Activated B cells |
CD77 |
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Leukocyte & platelet |
CD 47 |
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NK cell (2) |
CD16 & CD56 |
