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15 Cards in this Set

  • Front
  • Back

P-Class Pumps


  • Example:
  • ---Na+/K+ pump (ATPase) -Located in all cells
  • ---H+/K+ pump (ATPase) - Located in apical plasma membrane of stomach cells
  • ---Ca2+ pump (ATPase) - Located in plasma membrane of all cells, SR in muscle

Digoxin

  • Used in treatment of various heart conditions
  • Binds to EC aspect of Na+/K+ ATPase in the heart
  • ---Leads to more IC Na+ which leads to more IC Ca2+

F- and V- Class Pumps

  • Transport only protons
  • Doesn't require phosphoprotein intermediate
  • F- class: Mitochondria, bacterial plasma membranes and chloroplasts
  • V- Class: maintain low pH

ABC Superfamily

ATP binding cassette

  • Each is specific for a single group of related substances
  • Two transmembrane and two systolic domains
  • Impart resistance to anticancer drugs and antibiotics

MDR1

Multidrug-resistance transport protein


  • Cause of tumor cell resistance to some anticancer drugs
  • ATPase used to expel small hydrophobic drugs

Secondary Active Transport

Antiport

  • Na+/Ca2+ - in cardiomyocytes
  • Transport depends on [Na+]
  • ---Requires normal function of Na+/K+

Epithelial Transport

  • Luminal and Basolateral membranes have different transporter compositions

Rates of Ion permeation by method

ion channels > facilitated transport > ATPases > diffusion

Tetrodotoxin

  • Na+ Channel Blocker

Verapamil

  • Ca2+ Channel Blocker

Tetraethyl ammonium

  • K+ Channel Blocker

Nernst Equation

Membrane Potential

Where z is the charge of the ion in consideration

Where z is the charge of the ion in consideration

Approximate Equilibrium Potentials

Electroneutrality

  • The bulk of the intracellular and extracellular components are neutral
  • The ions that take part in charging the membrane are a tiny fraction of all ions in the cell

Examples

of

Primary Active Transport

  • Na+/K+ ATPase Pump
  • Ca2+ ATPase Pump
  • H+/K+ ATPase Pump (proton pump)