Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
|
aptosis
|
programmed cell death
|
|
|
necrosis
|
programmed cell death
|
|
|
aptosis is vital for
|
effective immune system,
normal development |
|
|
characterstics of aptosis
|
Chromosomal DNA cleaved into fragments
Change in the plasma membrane – phosphatidylserine in the outer leaflet |
|
|
aptosis depends on
|
intracellular proteolytic cascade that is mediated by caspes
|
|
|
2 best understood signaling pathways
|
extrinsic and intrinsic
|
|
|
extrinsic
|
activated by Fas, assembles into a disk, then leaveage of procapase 8/10. then exicutionar caspes is activated
|
|
|
intrinsic pathway
|
depends on mitochondri, releases cytocrome c
|
|
|
Bc12 regulate
|
intrinsic pathway of aptosis
|
|
|
Role of Bax and Bak
|
release mitochondrial intermembrane proteins into the intrinsic pathway
|
|
|
IAPS inhibit
|
caspases
|
|
|
inactivation of BH3
|
survival factor activates receptor, which activates AKT kinase which activates bad Bc12 and aptosis is blocked
|
|
|
How do you suppose over exrepssion of this fas protein might contribute to the survival of these tumor cells?
|
overexpression would protect the tumor cells by protecting them from killer lymphocytesy binding to the Fas ligand on the surface of killer lymphocytes, the secreted protein would prevent the Fas ligand from binding to Fas on the surface of tumor cells, thereby insu- lating them from death-inducing interactions with killer lymphocytes.
|
