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14 Cards in this Set
- Front
- Back
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1. Intrinsic Factor Pathophysiology?
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a. Glycoprotein secreted in the stomach that binds to B12.
b. The intrinsic factor-B12 complex then attaches to receptors in the distal ILEUM and is absorbed. |
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2. Anaemia type in children who quickly lose a large amount of blood?
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a. Usually normocytic anaemia.
b. The cells are normal, but there are fewer of them. |
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3. What 2 conditions may result in macrocytic anaemia w/LOW retic count other than folate/B12 deficiency?
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1. Hypothyroidism
2. Trisomy 21 b. All 4 are associated w/macrocytic anaemia and a LOW reticulocyte count as a result of inadequate bone marrow production. |
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4. What condition presents w/ macrocytic anaemia and a high retic count?
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a. Active haemolysis.
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5. What infants are most susceptible to B12 deficiency?
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a. Infants of mothers who Breast-feed and adhere to a strict vegan diet.
b. Malabsorption can also occur when the terminal ileum is absent or when infectious or inflammatory conditions compromise intestinal function. |
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6. Pathophys of Juvenile pernicious anaemia?
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a. These children are unable to secrete intrinsic factor and become B12 deficient between the ages of 1-5, when the supply of B12 passed Transplacentally from mother to child is exhausted.
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7. Presentation of Juvenile Pernicious anaemia?
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a. These children exhibit worsening irritability, loss of appetite, and decreased activity between ages 1-5.
b. They are at risk for permanent neurologic damage resulting from spinal cord demyelinization. |
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8. Tx of Juvenile Pernicious anaemia?
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a. IM B12.
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9. Other causes of macrocytic anaemia?
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a. Diphyllobothrium latum, which causes B12 deficiency.
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10. What are children who are exclusively fed on Goat’s milk at risk for?
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1. Deficiencies of B12 and folate
2. Brucellosis if the milk is unpasteurized. |
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11. Where is intrinsic factor produced?
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a. Gastric antrum.
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12. What should be considered in pts w/macrocytosis but normal B12 and folate levels?
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a. Atypical bone marrow pathology such as leukemia or myelodysplasia).
b. Referral to a paediatric haematologist would be warranted. |
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13. What other CBC abnormality is periodically seen in pts w/B12 deficiency?
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a. Thrombocytopenia. Thought to be related to impaired DNA synthesis and infective thrombopoiesis.
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14. Complete
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14. Complete
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