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6 Cards in this Set
- Front
- Back
I Extracellular Matrix
A. Overview 1. Structure |
Organized meshwork of macromolecules surronding and underlying cells
1) Ground substances 2) Fibers |
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I Extracellular Matrix
A. Overview 2. Functions |
Form, with water and other smalls molecules, the extracellular environment
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II Ground Sustance
A. GAG's |
GAGs are long. Unbranched polysaccharides
1) N-acetylglicosamine ou N-acetylgalactosamine is aways one of them. 2) GAGs are sulfataded and usually posses a uronic acid sugar, they have a strong negative charge 3) Are generally linket to core proteins 4) The attraction of active cátions, results in a heavily hydrated matrix (resists compression) 5) Ocupy large volumes of space 6) May be classified into four main groups |
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II Ground Sustance
B. Proteoglycans |
Consist of a core proteins from with many GAGs extend. Shaped like a bttle brush
1) May attach to hyaluronic acid via they core proteins 2) Heterogeneity 3) Fynction. Act as binding sites for growth factor and other signaling molecules and confer unique attributes to the extracelllular matrix |
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II Ground Sustance
C. Glycoproteins |
1. Fibronectin
2. Laminin 3. Entactin 4. Tenascin 5. Chondronectin 6. Osteonectin |
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III. Fibers
A. Collagen |
Is the most abundant structural protein of the extracellular maytix; Exist in at least 20 molecular types
1) Asemply into fibrls in two event: intracellular and extracellular. 2) Synthesis of tipe IV collagen 3) Elastic fibers a) elastin b) Fibrillin |