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41 Cards in this Set

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Warfarin

Anticoagulant


Inhibits vitamin K reductase hence not carboxylating factors II, XII, IX, X

Heparin


(...parin)

Anticoagulant


Binds & activates Antithrombin III. Binds factors IIa & Xa

LMW Heparin

Anticoagulant


Binds & activates Antithrombin III. Binds factor Xa

Hirudin


Hirugen

Anticoagulant


Inhibits thrombin by binding to active site

Bivalirudin

Anticoagulant


Derivative of hirudin, inhibits thrombin

Aspirin

Antiplatelet


Inhibits COX. Low TXA2 in platelets. Endothelium recover quickly producing PGI2 hence action

Ticlopidine

Antiplatelet


Irreversible antagonist of P2Y12 ADP receptor on platelets

Clopidogrel

Antiplatelet


Irreversible antagonist of P2Y12 ADP receptor on platelets

Prasugrel


(most used)

Antiplatelet


Irreversible antagonist of P2Y12 ADP receptor on platelets

Ticagrelor

Antiplatelet


Reversible antagonist of P2Y12 ADP receptor on platelets

Abciximab

IIb/IIIa (alphaIIbbetaIII) antagonist

Tirofiban / Eptifibatide

IIb/IIIa (alphaIIbbetaIII) antagonist

Epoprostenol

Prostaglandin agonist

Dipyridamole

Phosphodiesterase inhibitor, increases platelet cAMP levels

Streptokinase

Fibrinolytic agent

Tranexamic acid

Antifibrolytic (teeth extraction)

Aprotinin

Inhibitor of plasmin

Statins


Losartan

Inhibit HMG CoA reductase


SE: rhabdomyolysis, myalgia

Fibrates


Benzafibrate

PPAR-alpha antagonist. Increase beta oxidation in liver, lipoprotein lipase, lowers vLDL raises HDL


SE: rhabdomyolysis

Bile acid binding agents


Cholestipol

lowers cholesterol & LDL

Nitrates

Increase NO synthesis, VD, antiplatelet


SE: tolerance!

Propranolol

Beta blockers, decrease myocardial O2 demand.

Dihydropyridines

Class of Ca channel blockers .....dipines


SE: peripheral VD (utilised in high BP patients)

Phenylalkaylamines


Veramipril

Class of Ca channel blockers quite selective for the heart no peripheral VD


Benzothiazepines


Diltiazem

Intermetiate between other classes of Ca channel blockers

Hydrochlorothiazide

Diuretic. Block Na Cl symport in DCT, lower blood vol, and vasodilation


SE: electrolyte disturb

Enalapril

ACE inhibitors lower blood volume


SE: hyperkalemia

Losartan

Block AT1 receptor very common use


SE: hyperkalemia

Prasosin


....sin

Alpha 1 blocker, vasodilation

Pinacidil

Hyperpolarise cell mem by activating K channel, not very effective

alpha-MD

false transmitter, lower BP. Last chance!

Guanadrel

Last chance to lower BP!

Quinidine

CLASS Ia (moderate)


-Moderate reduction in P0 slope


-Increase APD, ERP




Arrhythmias: ventricular


Prevent paroxysmal recurrent atrial fibrillation



Lidocaine

CLASS Ib (weak)


-Small reduction in P0 slope


-Decrease APD, ERP




Arrhythmias: ventricular tachycardias


Used in MI

Flecanidine

CLASS Ic (strong)

-Large reduction in P0 slope


-No effect APD, ERP



Arrhythmias: WPW syndrome, CPVT, recurrent tachyarrhythmias

Atenolol

CLASS II Beta blockers. Block sympathetic drive.

Reduce rate, conduction & excitability


Arrhythmias: supraventricular tachycardia


MI

Amiodarone

CLASS III K-channel blockers

Delay repolarisation, increase APD, ERP


Arrhythmias: WPW syndrome, ventricular tachycardias, atrial fibrillation

Diltiazem

CLASS IV. Most effective at nodal tissue, reduce rate and conduction.


Arrhythmias: atrial fibrillation, paroxysmal supraventricular tachycardia

Digoxin

Vagal stimulant CLASS V


FEAR 2 up 2 down

Furosemide

Loop diuretic

Spirononlactone

K sparing diruetic