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41 Cards in this Set
- Front
- Back
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Warfarin |
Anticoagulant Inhibits vitamin K reductase hence not carboxylating factors II, XII, IX, X |
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Heparin (...parin) |
Anticoagulant Binds & activates Antithrombin III. Binds factors IIa & Xa |
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LMW Heparin |
Anticoagulant Binds & activates Antithrombin III. Binds factor Xa |
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Hirudin Hirugen |
Anticoagulant Inhibits thrombin by binding to active site |
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Bivalirudin |
Anticoagulant Derivative of hirudin, inhibits thrombin |
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Aspirin |
Antiplatelet Inhibits COX. Low TXA2 in platelets. Endothelium recover quickly producing PGI2 hence action |
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Ticlopidine |
Antiplatelet Irreversible antagonist of P2Y12 ADP receptor on platelets |
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Clopidogrel |
Antiplatelet Irreversible antagonist of P2Y12 ADP receptor on platelets |
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Prasugrel (most used) |
Antiplatelet Irreversible antagonist of P2Y12 ADP receptor on platelets |
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Ticagrelor |
Antiplatelet Reversible antagonist of P2Y12 ADP receptor on platelets |
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Abciximab |
IIb/IIIa (alphaIIbbetaIII) antagonist |
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Tirofiban / Eptifibatide |
IIb/IIIa (alphaIIbbetaIII) antagonist |
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Epoprostenol |
Prostaglandin agonist |
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Dipyridamole |
Phosphodiesterase inhibitor, increases platelet cAMP levels |
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Streptokinase |
Fibrinolytic agent |
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Tranexamic acid |
Antifibrolytic (teeth extraction) |
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Aprotinin |
Inhibitor of plasmin |
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Statins Losartan |
Inhibit HMG CoA reductase SE: rhabdomyolysis, myalgia |
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Fibrates Benzafibrate |
PPAR-alpha antagonist. Increase beta oxidation in liver, lipoprotein lipase, lowers vLDL raises HDL SE: rhabdomyolysis |
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Bile acid binding agents Cholestipol |
lowers cholesterol & LDL |
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Nitrates |
Increase NO synthesis, VD, antiplatelet SE: tolerance! |
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Propranolol |
Beta blockers, decrease myocardial O2 demand. |
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Dihydropyridines |
Class of Ca channel blockers .....dipines SE: peripheral VD (utilised in high BP patients) |
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Phenylalkaylamines Veramipril |
Class of Ca channel blockers quite selective for the heart no peripheral VD
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Benzothiazepines Diltiazem |
Intermetiate between other classes of Ca channel blockers |
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Hydrochlorothiazide |
Diuretic. Block Na Cl symport in DCT, lower blood vol, and vasodilation SE: electrolyte disturb |
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Enalapril |
ACE inhibitors lower blood volume SE: hyperkalemia |
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Losartan |
Block AT1 receptor very common use SE: hyperkalemia |
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Prasosin ....sin |
Alpha 1 blocker, vasodilation |
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Pinacidil |
Hyperpolarise cell mem by activating K channel, not very effective |
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alpha-MD |
false transmitter, lower BP. Last chance! |
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Guanadrel |
Last chance to lower BP! |
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Quinidine |
CLASS Ia (moderate) -Moderate reduction in P0 slope -Increase APD, ERP Arrhythmias: ventricular Prevent paroxysmal recurrent atrial fibrillation |
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Lidocaine |
CLASS Ib (weak) -Small reduction in P0 slope -Decrease APD, ERP Arrhythmias: ventricular tachycardias Used in MI |
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Flecanidine |
CLASS Ic (strong)
-Large reduction in P0 slope -No effect APD, ERP Arrhythmias: WPW syndrome, CPVT, recurrent tachyarrhythmias |
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Atenolol |
CLASS II Beta blockers. Block sympathetic drive.
Reduce rate, conduction & excitability Arrhythmias: supraventricular tachycardia MI |
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Amiodarone |
CLASS III K-channel blockers
Delay repolarisation, increase APD, ERP Arrhythmias: WPW syndrome, ventricular tachycardias, atrial fibrillation |
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Diltiazem |
CLASS IV. Most effective at nodal tissue, reduce rate and conduction. Arrhythmias: atrial fibrillation, paroxysmal supraventricular tachycardia |
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Digoxin |
Vagal stimulant CLASS V FEAR 2 up 2 down |
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Furosemide |
Loop diuretic
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Spirononlactone |
K sparing diruetic |
