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31 Cards in this Set
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Vincristine
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inhibits microtubules, for NHL, ALL, neurotoxic, SIADH; metabolized by liver
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Cris plays for NHL and got his brain injured
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Vinblastine
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inhibits microtubules, for HD, ALL, myelosuppressive; metabolized by liver
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Vinorelbine
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inhibits microtubules, for lymphomas, myelosuppressive; metabolized by liver
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Etopiside
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inhibits topoisomerase II; for lung, testes, lymp, peds; myelosuppressive
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Taxol
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inhibits microtubule depolymerization, for some GU and breast ca, myelosuppressive
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Taxotere
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inhibits microtubule depolymerization, for some GU and breast ca, myelosuppressive
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Irinotecan
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For colon cancer; inhibits topoisomerase I; causes diarrhea; prodrug
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irene had to go to the can
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Doxorubicin (adriamycin)
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antibiotic for many cancers (not lung or colon); intercalates between DNA bases and interrupts RNA synthesis; forms free radicals (cardiac toxic) so give DEXRAZOXANE; myelosuppressive, strong emetic agent
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Daunorubicin (daunomycin)
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for AML/ALL, intercalates between DNA bases
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Dexrazoxane
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free radical scavenger; give with doxorubicin
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Asparaginase
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Enzyme that depletes L-asparagine; inhibits some liver fxn
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Allopurinol
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for tumor lysis syndrome/hyperuricemia; inhibits xanthine oxidase which catalyzes formation of uric acid
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Raspuricase
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for tumor lysis syndrome, hyperuricemia; turns uric acid to highly soluble allantoin
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5-fluorouracil
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continuous infusion inhibits thymidine production/DNA synthesis, gives mucositis; Bolus inhibits RNA and can cause myelosuppression. Either can cause for cardiac/hepatotoxicity. for breast, Colon, GI, bladder, breast, head and neck. prodrug converted to F-dUMP
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Cytarabine
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for AML/ALL, prodrug must be phosphorylated x3 to inhibit DNA polymerase (S); continuous IV infusion, myelosuppresive, high dose CNS and pulm toxic
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Gemcitibine
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for bladder, lung, pancreas; prodrug must be phosph x1 to terminate DNA strand formation; radiosensitizer; mild myelosuppression
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Methotrexate
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for bladder, lymphoma, brain, osteosarcoma, childhood; inhibits folic acid conversion (S), oral or IV or intrathecally, prodrug converted w/i cell, excreted renally, administer with LEUCORVIN to save nl tissue and lots of fluid
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Leucorvin
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give with metrotrexate to rescue nl cells. bypasses the blocked step in folate metabolism
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Ritixumab
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binds CD20, for CD20+ non-hodgkins lymphomas
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Cyclophosphamide
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alkylating agent with a broad range of activity. can be resisted in various ways. prodrug. moderate N/V, myelosuppression
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Ifosfamide
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akylating agent with broad activity, some N/V
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Cisplatin
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platinum based agent that disrupts DNA fxn. if extravasated, give Na Thiosulfate. Can cause renal insuff, so give lots of fluids and diurese. Major N/V
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Carboplatin
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platinum based agent that disrupts DNA fxn. Myelosuppression, moderate N/V, moderate nephrotoxicity
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Sodium thiosulfate
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antidote to cisplatin
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EPO
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for anemia due to cancer
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GM-CSF
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stimulates neutrophil and Eos production
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G-CSF
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stimulates neutrophil production
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Imatinib (Gleevec)
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for CML, GIST, Ph+ ALL. inhibits BCRabl tyrosine kinase/c-kit
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Tamoxifen
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for estrogen R positive breast cancer, blocks Receptor; increases chance of endometrial cancer, most commonly causes hot flashes, bone pain/hypercalcemia
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Flutamide
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antiandrogen for prostate cancer. can cause hepatotoxicity
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Leupromide
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GnRH analogue, for prostate cancer; first causes surge in FSH and LH so give with anti-androgen to avoid a flare-up/hot flashes
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