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5 Cards in this Set
- Front
- Back
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The Cell Cycle |
Interphase: cell is growing but not dividing (G1, S, and G2) G1: growth phase, longest phase, cell prepares for S G0: resting, no cell division S: DNA synthesis G2: cell prepares for M M: mitosis After M, G1 starts again |
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Characteristics of Cancer |
Cancer cells are mostly in M stage Neoplastic cells: rapid proliferation, invasive growth, metastasis, immortality |
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Treatment Approaches to Cancer |
Surgery: for solid tumor cancers Radiation Drug therapy: for disseminated cancers like leukemia, small cell lung cancer, Hodgkin’s disease Drug Classes: cytotoxic agents (most common), hormones and hormone antagonists, biologic response modifiers or immunotherapies, targeted drugs |
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Major Toxicities for Chemotherapy |
Bone marrow suppression (most serious): neutropenia (less than 500), thrombocytopenia (less than 10x10^3), anemia (HgB less than 8) Digestive tract injury: stomatitis, diarrhea N/V Alopecia Reproductive toxicity |
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Strategies for Chemotherapy |
Intermittent chemotherapy Combination chemotherapy: suppression of drug resistance, increased cancer destruction, reduced harm to normal cells Drug selection: each drug should be effective by itself, different MOA, and minimally overlapping toxicities Regional drug delivery Supportive drugs |
