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44 Cards in this Set
- Front
- Back
azetasolamide
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carbonic anhydrase inhibitor, treats glaucoma
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mephenytoin
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anitepileptic drug, hyrdoxylated in the S-enantiomer
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glycoside digitalis
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inhibit Na/K pump, treat congestive heart failure
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Heparin
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glycosaminoglycan that is stored in mast cells
binds antithrombin to activate it -used during treatment for MI and deep venous thrombosis |
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bortezomib
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used to treat multiple myeloma and inhibits the proteasome
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isoniazid
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treatment of tuberculosis
fast and slow metabolizers |
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physostigmine
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competative reversible inhibitor of Achesterase
-treat myasthenia gravis |
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ACE inhibitors
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-(angiotensin converting enzyme)
inhibit formating of Angiotensin II |
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alkylphosphate insectisides (malathion)
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-block ACHesterase
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acarbose
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-alpha-glucosidase inhibitor
-works in intestine to slow down digestion of carbohydrates to facilitate post digestive blood glucose control |
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Orlistat
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anti-obesity drug that inhibits pancreatic and gastric lipase, resulting in blockage of fat absorption
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sulfonylureas
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-used in the management of type 2 diabetes
-stimulate preformed insulin releases from the pancreas |
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thiazolidinediones
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-increases the cells' responsiveness to circulating insulin
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biguanides (metformin)
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-management of type 2 diabetes
-inhibit hepatic gluconeogenesis to decrease circulating glucose in post absorptive state |
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Statins
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-competitive inhibitors of HMG-CoA reductase, reducing serum level of cholesterol
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Ursodeoxycholate
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-used to inhibit the formation of cholesterol gallstones, decreases the content of cholesterol in bile
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cholestyramine (bile acid sequestrant)
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bind wih bile acids that are bound to LDL
-this causes fecal loss of LDL |
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gemfibrozil
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-fibrate class of lipid-lowering agents
-activates lipoprotein lipase and decreases VLDLs |
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Nitrates
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release NO and are used in control of blood pressure
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Selective serotonin reuptake inhibitors
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promote serotonin's actions and are used to treat depression
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trimethoprim
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folate analog that binds specifically to bacterial dihydrofolate reductase
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Mycophenolic acid
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rejections
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Hydroxyurea
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antineoplastic agent that inhibits Ribonucleaside diphosphate reductase
-used to treat chronic myelogenous leukemia |
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Allopurinol
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inhibitor of xanthine oxidase
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Vinblastine
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microtubule depolymerizing drug
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Taxol
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microtubule polymerizing drug
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Gleevec
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treatment of chronic myelogenous leukemia by binding ATP site of bcr-abl
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desferrioxamine
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iron chelator to treat iron overload
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Hydroxyurea
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induce HbF
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Opioids
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pharmacologic agents that mimic the effects of endorphins
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etoposide
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inhibits topoisomerase and is used in cancer treatment
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Quinolone Antibiotics (ciproflaxin)
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inhibit DNA gyrase and are used for infections including UTI's
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Zidovudine (AZT, ZDV)
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analog of thymidine lacking the 3'hydroxyl and inhibiting viral DNA polymerase
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Dideoxyinosine and zalcitabine
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analogs of dntps used to treat HIV
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Rifampin
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bacterial antibiotic that inhibits the beta-subunit of bacterial DNA-dependant RNA polymerase
-used to treat tuberculosis of meningitis |
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Actinomycin D
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binds to GC pairs to inhibit transcription
-highly toxic but used in some pediatric cancers |
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alpha-Amanitin
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-cellular toxin that binds and inhibits RNA pol II
-ingestion of the mushroom containing it results in liver toxicity and possibly death |
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Streptomycin
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binds to 30S subunit of ribosome and inhibits initiation
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Tetracycline
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binds to 30S subunit of ribosome and inhibits aatRNA binding
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Synthetic retinoids
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-potent inducers of numerous embryonic genes
-isotretinoin->birth defects |
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Gefitinib (Iressa)
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orally active small molecule inhibitor of EGFR tyrosine kinase used in treatment of carcinoma of the lung
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Remicade and Enbrel
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biologic agents that are used in the treatment of autoimmune disease by triggering TNF receptors, inducing cells to undergo apoptosis
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Avastin
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inhibits VEGF's and is used to treat colon cancer
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valinomycin
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makes inner mito membrane permeable to K+
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